ArticleOncotarget2011
Wnt and Kras signaling-dark siblings in lung cancer.
Article in Oncotarget, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Sex differences in the tumor promoting effects of tobacco smoke in a cRaf transgenic lung cancer disease model.Archives of toxicology · 2024Article
- Association of decreased estimated glomerular filtration rate with lung cancer risk in the Korean population.Epidemiology and health · 2024Article
- Implementation of CRISPR/Cas9 Genome Editing to Generate Murine Lung Cancer Models That Depict the Mutational Landscape of Human Disease.Frontiers in cell and developmental biology · 2021Article
- A probabilistic method for leveraging functional annotations to enhance estimation of the temporal order of pathway mutations during carcinogenesis.BMC bioinformatics · 2019Article
- Chronic Cigarette Smoke-Induced Epigenomic Changes Precede Sensitization of Bronchial Epithelial Cells to Single-Step Transformation by KRAS Mutations.Cancer cell · 2017Article
- WNT signaling - lung cancer is no exception.Respiratory research · 2017Review
- WIF-1 gene inhibition and Wnt signal transduction pathway activation in NSCLC tumorigenesis.Oncology letters · 2017Article
- Ras-activated RSK1 phosphorylates EBP50 to regulate its nuclear localization and promote cell proliferation.Oncotarget · 2016Article
- Ras regulates SCF(β-TrCP) protein activity and specificity via its effector protein NORE1A.The Journal of biological chemistry · 2014Article
- GSK-3 as potential target for therapeutic intervention in cancer.Oncotarget · 2014Review
- Article
- α-catenin. A tumor suppressor beyond adherens junctions.Cell cycle (Georgetown, Tex.) · 2014Article
- Lung cancer tumorigenicity and drug resistance are maintained through ALDH(hi)CD44(hi) tumor initiating cells.Oncotarget · 2013Article
- Overexpression of a novel regulator of p120 catenin, NLBP, promotes lung adenocarcinoma proliferation.Cell cycle (Georgetown, Tex.) · 2013Article
- Combination therapy with anti-ErbB3 monoclonal antibodies and EGFR TKIs potently inhibits non-small cell lung cancer.Oncotarget · 2013Article
- Developmental pathways in colon cancer: crosstalk between WNT, BMP, Hedgehog and Notch.Cell cycle (Georgetown, Tex.) · 2012Review
- Advances in targeting signal transduction pathways.Oncotarget · 2012Review
- The role of Sox genes in lung morphogenesis and cancer.International journal of molecular sciences · 2012Review
- MiR-365 regulates lung cancer and developmental gene thyroid transcription factor 1.Cell cycle (Georgetown, Tex.) · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Aberrant Kras signaling is observed in a high percentage of human lung cancers while activating mutations in the Wnt/b-catenin signaling pathway are only rarely found. Our recent work has shown that the combined activation of both Kras and Wnt/b-catenin signaling leads to a dramatic increase in both tumor incidence and size. Moreover, lung tumors generated by the combined activation of both of these pathways exhibit a distinct phenotype similar to embryonic progenitors found in the developing lung. Thus, combinatorial activation of Kras and Wnt/b-catenin pathways leads to a significant increase in lung tumor formation characterized by a more progenitor like phenotype.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.