Trial reportEuropean heart journal2011
Combustion-derived nanoparticulate induces the adverse vascular effects of diesel exhaust inhalation.
Trial report in European heart journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
87 citing papers in PubMed, 3 syntheses or guidelines pooled it, 221 citations in OpenAlex.
- Short-term Exposure to Air Pollution and Ischemic Stroke: A Systematic Review and Meta-analysis.Neurology · 2023Pooled it
- Short term exposure to air pollution and stroke: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2015Pooled it
- Global association of air pollution and heart failure: a systematic review and meta-analysis.Lancet (London, England) · 2013Pooled it
- First-in-human controlled inhalation of thin graphene oxide nanosheets to study acute cardiorespiratory responses.Nature nanotechnology · 2024Trial
- Acute cardiovascular effects of controlled exposure to dilute Petrodiesel and biodiesel exhaust in healthy volunteers: a crossover study.Particle and fibre toxicology · 2021Trial
- Effect of Reducing Ambient Traffic-Related Air Pollution on Blood Pressure: A Randomized Crossover Trial.Hypertension (Dallas, Tex. : 1979) · 2021Trial
- Respiratory and cardiovascular responses to walking down a traffic-polluted road compared with walking in a traffic-free area in participants aged 60 years and older with chronic lung or heart disease and age-matched healthy controls: a randomised, crossover study.Lancet (London, England) · 2018Trial
- Pretreatment with Antioxidants Augments the Acute Arterial Vasoconstriction Caused by Diesel Exhaust Inhalation.American journal of respiratory and critical care medicine · 2016Trial
- Controlled human wood smoke exposure: oxidative stress, inflammation and microvascular function.Particle and fibre toxicology · 2012Trial
- Detection and Proinflammatory Effects of BTEX within the Human Atherosclerotic Plaque.Environmental science & technology · 2025Observational
- Demonstration of particulate matter characterization from HVO-blended diesel using an integrated multi-instrument approach.Scientific reports · 2025Article
- Advanced Diesel Powertrains for Underground Mining Mobile Equipment.Mining, metallurgy & exploration · 2025Article
- Differential Cytotoxicity and Inflammatory Responses to Particulate Matter Components in Airway Structural Cells.International journal of molecular sciences · 2025Article
- Controlled human exposures: a review and comparison of the health effects of diesel exhaust and wood smoke.Particle and fibre toxicology · 2024Review
- Concentration-Response Functions Relating Concentration and Duration of Ambient Traffic-Related Air Pollution Exposure to Systolic Blood Pressure.Environmental health perspectives · 2024Article
- Biological effects of diesel exhaust inhalation. III cardiovascular function.Inhalation toxicology · 2024Article
- HIPTox-Hazard Identification Platform to Assess the Health Impacts from Indoor and Outdoor Air Pollutant Exposures, through Mechanistic Toxicology: A Single-Centre Double-Blind Human Exposure Trial Protocol.International journal of environmental research and public health · 2024Article
- Epidemiology, Mechanisms and Prevention in the Etiology of Environmental Factor-Induced Cardiovascular Diseases.Journal of environmental science and public health · 2024Article
- The contribution of the exposome to the burden of cardiovascular disease.Nature reviews. Cardiology · 2023Review
- Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 3 countries.
Funding
Abstract
aimExposure to road traffic and air pollution may be a trigger of acute myocardial infarction, but the individual pollutants responsible for this effect have not been established. We assess the role of combustion-derived-nanoparticles in mediating the adverse cardiovascular effects of air pollution. METHODS AND
resultsTo determine the in vivo effects of inhalation of diesel exhaust components, 16 healthy volunteers were exposed to (i) dilute diesel exhaust, (ii) pure carbon nanoparticulate, (iii) filtered diesel exhaust, or (iv) filtered air, in a randomized double blind cross-over study. Following each exposure, forearm blood flow was measured during intra-brachial bradykinin, acetylcholine, sodium nitroprusside, and verapamil infusions. Compared with filtered air, inhalation of diesel exhaust increased systolic blood pressure (145 ± 4 vs. 133 ± 3 mmHg, P< 0.05) and attenuated vasodilatation to bradykinin (P= 0.005), acetylcholine (P= 0.008), and sodium nitroprusside (P< 0.001). Exposure to pure carbon nanoparticulate or filtered exhaust had no effect on endothelium-dependent or -independent vasodilatation. To determine the direct vascular effects of nanoparticulate, isolated rat aortic rings (n= 6-9 per group) were assessed in vitro by wire myography and exposed to diesel exhaust particulate, pure carbon nanoparticulate and vehicle. Compared with vehicle, diesel exhaust particulate (but not pure carbon nanoparticulate) attenuated both acetylcholine (P< 0.001) and sodium-nitroprusside (P= 0.019)-induced vasorelaxation. These effects were partially attributable to both soluble and insoluble components of the particulate.
conclusionCombustion-derived nanoparticulate appears to predominately mediate the adverse vascular effects of diesel exhaust inhalation. This provides a rationale for testing environmental health interventions targeted at reducing traffic-derived particulate emissions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.