ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Cortical stimulation evokes abnormal responses in the dopamine-depleted rat basal ganglia.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 104 citations in OpenAlex.
- Proportional-Integral Controller-Based Deep Brain Stimulation Strategy for Controlling Excitatory-Inhibitory Network Synchronization.Proceedings of the ... American Control Conference. American Control Conference · 2025Article
- Whole-Brain Confocal Imaging Provides an Accurate Global View of the Nigral Dopamine System.Diagnostics (Basel, Switzerland) · 2025Article
- Computational model for control of hand movement in Parkinson's disease using deep brain stimulation.Experimental brain research · 2025Article
- Synaptic Changes in Pallidostriatal Circuits Observed in the Parkinsonian Model Triggers Abnormal Beta Synchrony with Accurate Spatio-temporal Properties across the Basal Ganglia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Dynamics of parkinsonian oscillations mediated by transmission delays in a mean-field model of the basal ganglia.Frontiers in cellular neuroscience · 2024Article
- Closed-loop modulation of model parkinsonian beta oscillations based on CAR-fuzzy control algorithm.Cognitive neurodynamics · 2023Article
- Synaptic network structure shapes cortically evoked spatio-temporal responses of STN and GPe neurons in a computational model.Frontiers in neuroinformatics · 2023Article
- Deep brain stimulation rectifies the noisy cortex and irresponsive subthalamus to improve parkinsonian locomotor activities.NPJ Parkinson's disease · 2022Article
- Subthalamic nucleus stabilizes movements by reducing neural spike variability in monkey basal ganglia.Nature communications · 2022Article
- Motor cortico-nigral and cortico-entopeduncular information transmission and its modulation by buspirone in control and after dopaminergic denervation.Frontiers in pharmacology · 2022Article
- The Origin of Abnormal Beta Oscillations in the Parkinsonian Corticobasal Ganglia Circuits.Parkinson's disease · 2022Review
- Cell Type-Specific Decrease of the Intrinsic Excitability of Motor Cortical Pyramidal Neurons in Parkinsonism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Elimination of the Cortico-Subthalamic Hyperdirect Pathway Induces Motor Hyperactivity in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Striatal Direct Pathway Targets Npas1The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Abnormal Cortico-Basal Ganglia Neurotransmission in a Mouse Model of l-DOPA-Induced Dyskinesia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Adaptive Parameter Modulation of Deep Brain Stimulation Based on Improved Supervisory Algorithm.Frontiers in neuroscience · 2021Article
- Dysregulation of external globus pallidus-subthalamic nucleus network dynamics in parkinsonian mice during cortical slow-wave activity and activation.The Journal of physiology · 2020Article
- Synaptic and cellular plasticity in Parkinson's disease.Acta pharmacologica Sinica · 2020Review
- Model-Based Evaluation of Closed-Loop Deep Brain Stimulation Controller to Adapt to Dynamic Changes in Reference Signal.Frontiers in neuroscience · 2019Article
- Verifying Feighner's Hypothesis; Anorexia Nervosa Is Not a Psychiatric Disorder.Frontiers in psychology · 2019Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The motor cortex (MC) sends massive projections to the basal ganglia. Motor disabilities in patients and animal models of Parkinson's disease (PD) may be caused by dopamine (DA)-depleted basal ganglia that abnormally process the information originating from MC. To study how DA depletion alters signal transfer in the basal ganglia, MC stimulation-induced (MC-induced) unitary responses were recorded from the basal ganglia of control and 6-hydroxydopamine-treated hemi-parkinsonian rats anesthetized with isoflurane. This report describes new findings about how DA depletion alters MC-induced responses. MC stimulation evokes an excitation in normally quiescent striatal (Str) neurons projecting to the globus pallidus external segment (GPe). After DA-depletion, the spontaneous firing of Str-GPe neurons increases, and MC stimulation evokes a shorter latency excitation followed by a long-lasting inhibition that was invisible under normal conditions. The increased firing activity and the newly exposed long inhibition generate tonic inhibition and a disfacilitation in GPe. The disfacilitation in GPe is then amplified in basal ganglia circuitry and generates a powerful long inhibition in the basal ganglia output nucleus, the globus pallidus internal segment. Intra-Str injections of a behaviorally effective dose of DA precursor l-3,4-dihydroxyphenylalanine effectively reversed these changes. These newly observed mechanisms also support the generation of pauses and burst activity commonly observed in the basal ganglia of parkinsonian subjects. These results suggest that the generation of abnormal response sequences in the basal ganglia contributes to the development of motor disabilities in PD and that intra-Str DA supplements effectively suppress abnormal signal transfer.
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