ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Genetic dissection of EphA receptor signaling dynamics during retinotopic mapping.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Article
- Wiring subcortical image-forming centers: Topography, laminar targeting, and map alignment.Current topics in developmental biology · 2021Review
- New insights on the modeling of the molecular mechanisms underlying neural maps alignment in the midbrain.eLife · 2020Article
- Visual Maps Development: Reconsidering the Role of Retinal Efnas and Basic Principle of Map Alignment.Frontiers in cellular neuroscience · 2018Article
- Article
- Wiring visual systems: common and divergent mechanisms and principles.Current opinion in neurobiology · 2017Review
- EphA4 has distinct functionality from EphA7 in the corticothalamic system during mouse brain development.The Journal of comparative neurology · 2016Article
- Estimating the location and size of retinal injections from orthogonal images of an intact retina.BMC neuroscience · 2015Article
- Stochastic Interaction between Neural Activity and Molecular Cues in the Formation of Topographic Maps.Neuron · 2015Article
- Quantitative assessment of computational models for retinotopic map formation.Developmental neurobiology · 2015Article
- Defective response inhibition and collicular noradrenaline enrichment in mice with duplicated retinotopic map in the superior colliculus.Brain structure & function · 2015Article
- Target-independent ephrina/EphA-mediated axon-axon repulsion as a novel element in retinocollicular mapping.Neuron · 2014Article
- Copy number variation analysis in 98 individuals with PHACE syndrome.The Journal of investigative dermatology · 2013Article
- On the Importance of Countergradients for the Development of Retinotopy: Insights from a Generalised Gierer Model.PloS one · 2013Article
- The evolutionary and genetic origins of consciousness in the Cambrian Period over 500 million years ago.Frontiers in psychology · 2013Article
- Identification of HMX1 target genes: a predictive promoter model approach.Molecular vision · 2013Article
- Immunoproteomic analysis of potential serum biomarker candidates in human glaucoma.Investigative ophthalmology & visual science · 2012Article
- Article
- Epigenetic regulation of retinal development and disease.Journal of ocular biology, diseases, and informatics · 2011Article
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3 authors.
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Abstract
Retinal ganglion cells (RGCs) project axons from their cell bodies in the eye to targets in the superior colliculus of the midbrain. The wiring of these axons to their synaptic targets creates an ordered representation, or "map," of retinal space within the brain. Many lines of experiments have demonstrated that the development of this map requires complementary gradients of EphA receptor tyrosine kinases and their ephrin-A ligands, yet basic features of EphA signaling during mapping remain to be resolved. These include the individual roles played by the multiple EphA receptors that make up the retinal EphA gradient. We have developed a set of ratiometric "relative signaling" (RS) rules that quantitatively predict how the composite low-nasal-to-high-temporal EphA gradient is translated into topographic order among RGCs. A key feature of these rules is that the component receptors of the gradient--in the mouse, EphA4, EphA5, and EphA6--must be functionally equivalent and interchangeable. To test this aspect of the model, we generated compound mutant mice in which the periodicity, slope, and receptor composition of the gradient are systematically altered with respect to the levels of EphA4, EphA5, and a closely related receptor, EphA3, that we ectopically express. Analysis of the retinotopic maps of these new mouse mutants establishes the general utility of the RS rules for predicting retinocollicular topography, and demonstrates that individual EphA gene products are approximately equivalent with respect to axon guidance and target selection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.