ArticleJournal of clinical microbiology2011
Characterization of Helicobacter pylori cagA and vacA genotypes among Alaskans and their correlation with clinical disease.
Article in Journal of clinical microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 54 citations in OpenAlex.
- Review
- The prevalence and risk factors ofMicrobiota in health and disease · 2024Article
- Genetic diversity of Helicobacter pylori type IV secretion system cagI and cagN genes and their association with clinical diseases.Scientific reports · 2023Article
- Correlation analysis of gastric mucosal lesions withAnnals of translational medicine · 2022Article
- Article
- The Relation Between Host TLR9 -1486T/C, rs187084 Gene Polymorphisms andPolish journal of microbiology · 2022Article
- Interruption ofBiomolecules & therapeutics · 2021Article
- Presence ofJournal of medical microbiology · 2020Article
- Detection of Helicobacter pylori and its virulence genes (cagA, dupA, and vacA) among patients with gastroduodenal diseases in Chris Hani Baragwanath Academic Hospital, South Africa.BMC gastroenterology · 2019Article
- Genetic diversity and amino acid sequence polymorphism in Helicobacter pylori CagL hypervariable motif and its association with virulence markers and gastroduodenal diseases.Cancer medicine · 2019Article
- Review
- H. pylori-associated pathologic findings among Alaska native patients.International journal of circumpolar health · 2018Article
- Helicobacter pylori infection downregulates duodenal CFTR and SLC26A6 expressions through TGFβ signaling pathway.BMC microbiology · 2018Article
- Gastric cancer in Alaska Native people: A cancer health disparity.World journal of gastroenterology · 2018Article
- The Evaluation of Diagnostic and Predictive Values ofIranian journal of pathology · 2018Article
- Prevalence ofInternational journal of microbiology · 2018Article
- Helicobacter pylori cagA and vacA genes in dyspeptic Ghanaian patients.BMC research notes · 2017Article
- Article
- Helicobacter pylori isolated from Iranian drinking water: vacA, cagA, iceA, oipA and babA2 genotype status and antimicrobial resistance properties.FEBS open bio · 2016Article
- Helicobacter pylori in bottled mineral water: genotyping and antimicrobial resistance properties.BMC microbiology · 2016Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helicobacter pylori infection is common in Alaska. The development of severe H. pylori disease is partially determined by the virulence of the infecting strain. Here we present vacA and cagA genotype data for H. pylori strains isolated from Alaskans and their correlation with clinical disease. We enrolled patients scheduled for esophagogastroduodenoscopy and positive for H. pylori infection. Gastric biopsy specimens from the stomach antrum and fundus were cultured. We performed PCR analysis of the H. pylori vacA gene and for the presence of the cagA gene and cagA empty site. We genotyped 515 H. pylori samples from 220 Native and 66 non-Native Alaskans. We detected the cagA gene in 242/286 (85%) persons; of 222 strains that could be subtyped, 95% (212) were non-Asian cagA and 3% (6) were East Asian cagA. After removing mixed infections (n = 17), 83% of H. pylori strains had either the vacA s1m1 (120/269) or s2m2 (103/269) genotype. Sixty-six percent (68/103) of H. pylori strains with the vacA s2m2 genotype also contained the cagA gene. Infection with an H. pylori strain having the cagA gene or vacA s1m1 genotype (compared with s1m2 and s2m2) was associated with a decreased risk of esophagitis (P = 0.003 and 0.0003, respectively). Infection with an H. pylori strain having the vacA s1m1 genotype (compared with s1m2 and s2m2) was associated with an increased risk of peptic ulcer disease (PUD) (P = 0.003). The majority of H. pylori strains in this study carried the non-Asian cagA gene and either the vacA s1m1 or s2m2 genotype. A majority of H. pylori strains with the vacA s2m2 genotype also contained the cagA gene. There was an association of H. pylori genotype with esophagitis and PUD.
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