ArticleDevelopment (Cambridge, England)2011
no child left behind encodes a novel chromatin factor required for germline stem cell maintenance in males but not females.
Article in Development (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
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- Review
- Epigenetic regulation of drosophila germline stem cell maintenance and differentiation.Developmental biology · 2021Review
- Adaptation of codon and amino acid use for translational functions in highly expressed cricket genes.BMC genomics · 2021Article
- Coordinated control of adiposity and growth by anti-anabolic kinase ERK7.EMBO reports · 2021Article
- WIPI2 depletion inhibits the growth of hepatocellular carcinoma cells through the AMPK signaling pathway.Oncology reports · 2020Article
- PWP1 promotes nutrient-responsive expression of 5S ribosomal RNA.Biology open · 2018Article
- Maternal Proteins That Are Phosphoregulated upon Egg Activation Include Crucial Factors for Oogenesis, Egg Activation and Embryogenesis inG3 (Bethesda, Md.) · 2018Article
- Protecting and Diversifying the Germline.Genetics · 2018Review
- Stem cell autotomy and niche interaction in different systems.World journal of stem cells · 2015Review
- Genetic, immunofluorescence labeling, and in situ hybridization techniques in identification of stem cells in male and female germline niches.Methods in molecular biology (Clifton, N.J.) · 2013Article
- Jak-STAT regulation of cyst stem cell development in the Drosophila testis.Developmental biology · 2012Article
- Transcriptional regulation during Drosophila spermatogenesis.Spermatogenesis · 2012Article
- Recent advances in Drosophila male germline stem cell biology.Spermatogenesis · 2012Article
- Phf7 controls male sex determination in the Drosophila germline.Developmental cell · 2012Article
- Tissue, cell type and stage-specific ectopic gene expression and RNAi induction in the Drosophila testis.Spermatogenesis · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Male and female germ cells follow distinct developmental paths with respect to germline stem cell (GSC) production and the types of differentiated progeny they produce (sperm versus egg). An essential aspect of germline development is how sexual identity is used to differentially regulate the male and female germ cell genomes to allow for these distinct outcomes. Here, we identify a gene, no child left behind (nclb), that plays very different roles in the male versus female germline in Drosophila. In particular, nclb is required for GSC maintenance in males, but not in females. Male GSCs mutant for nclb are rapidly lost from the niche, and begin to differentiate but cannot complete spermatogenesis. We further find that nclb encodes a member of a new family of conserved chromatin-associated proteins. NCLB interacts with chromatin in a specific manner and is associated with sites of active transcription. Thus, NCLB appears to be a novel chromatin regulator that exhibits very different effects on the male and female germ cell genomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.