ArticleInternational journal of pediatric otorhinolaryngology2011
Prevalence of Epstein-Barr virus in tonsils and adenoids of United Arab Emirates nationals.
Article in International journal of pediatric otorhinolaryngology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Adenotonsillectomy is associated with increased risk and disease activity in pediatric-onset multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026Article
- Herpesvirus and Adenotonsillar Hypertrophy in Chinese Children: An Epidemiological and Clinical Analysis.World journal of otorhinolaryngology - head and neck surgery · 2026Article
- Epstein-Barr virus in tonsillar tissue of Iranian children with tonsillar hypertrophy: Quantitative measurement by real-time PCR.World journal of otorhinolaryngology - head and neck surgery · 2024Article
- Glandular Fever Testing in Patients Presenting With Tonsillitis: A Retrospective Study.Cureus · 2023Article
- Association of Human Papillomavirus and Epstein-Barr Virus Infection with Tonsil Cancer in Northeastern Thailand.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- PCR Detection of Epstein-Barr Virus (EBV) DNA in Patients with Head and Neck Squamous Cell Carcinoma, in Patients with Chronic Tonsillitis, and in Healthy Individuals.BioMed research international · 2022Article
- Association of infections with multiple sclerosis in Gulf Cooperation Council countries: a review.The Journal of international medical research · 2020Review
- Epstein-Barr virus is present in the brain of most cases of multiple sclerosis and may engage more than just B cells.PloS one · 2018Article
- The ubiquity of asymptomatic respiratory viral infections in the tonsils and adenoids of children and their impact on airway obstruction.International journal of pediatric otorhinolaryngology · 2016Article
- The Role of Epstein-Barr Virus in Adenoid and Tonsil Enlargement in Nigerian Children.Nigerian medical journal : journal of the Nigeria Medical AssociationReview
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveGiven that Epstein-Barr virus (EBV) often inhabits human tonsils and adenoids, it remains to be distinctively determined its prevalence and in which cell and microenvironment the virus is present.
methodsTo determine the prevalence of EBV in the tonsils and adenoids of the United Arab Emirates (UAE) nationals and to provide a basis for understanding the origin and biology of EBV-infected cells, the immunophenotype of all EBV-infected cells in 46 tonsils and 46 adenoids was determined by EBER in situ hybridization and immunohistochemistry with monoclonal antibodies to T cells (CD3), B cells (CD20), and epithelial cells (cytokeratin AE1/AE3), as well as immunostaining with antibodies to EBV latent membrane protein-1 (LMP-1).
resultsEBV was found in 43% of tonsillectomy specimens and 15% of adenoidectomy specimens. All EBV-infected cells were found to be B lymphocytes. About 90% of the infected B cells are found in the interfollicular regions of tonsils and adenoids and the remaining 10% are found within the follicles. There is no significant association between EBV infection, age (P=0.324) and gender (P=0.442).
conclusionEBV is associated with tonsillar hypertrophy and is prevalent in 43% of our cases. EBV is only detected in B lymphocytes and we believe that B lymphocytes are sites of primary infection and latency. In situ hybridization is the gold standard for the detection of EBV in tissue.
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