Trial reportTrials2011
Improving mood with psychoanalytic and cognitive therapies (IMPACT): a pragmatic effectiveness superiority trial to investigate whether specialised psychological treatment reduces the risk for relapse in adolescents with moderate to severe unipolar depression: study protocol for a randomised controlled trial.
Trial report in Trials, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 4 syntheses or guidelines pooled it, 127 citations in OpenAlex.
- The Evidence-Base for Psychodynamic Psychotherapy With Children and Adolescents: A Narrative Synthesis.Frontiers in psychology · 2021Pooled it
- Psychological therapies versus antidepressant medication, alone and in combination for depression in children and adolescents.The Cochrane database of systematic reviews · 2014Pooled it
- Psychoanalytic/psychodynamic psychotherapy for children and adolescents who have been sexually abused.The Cochrane database of systematic reviews · 2013Pooled it
- Interventions for preventing relapse and recurrence of a depressive disorder in children and adolescents.The Cochrane database of systematic reviews · 2012Pooled it
- Exploring fatigue in clinically depressed adolescents: a secondary analysis of the IMPACT study sample.BMC psychology · 2026Trial
- Dynamics of depression symptoms in adolescents during three types of psychotherapy and post-treatment follow-up.Journal of child psychology and psychiatry, and allied disciplines · 2025Trial
- The experience of cognitive behavioural therapy in depressed adolescents who are fatigued.Psychology and psychotherapy · 2022Trial
- A comprehensive mapping of outcomes following psychotherapy for adolescent depression: The perspectives of young people, their parents and therapists.European child & adolescent psychiatry · 2021Trial
- Mechanisms of change and heterogeneous treatment effects in psychodynamic and cognitive behavioural therapy for patients with depressive disorder: a randomized controlled trial.BMC psychology · 2021Trial
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- Toward precision therapeutics: general and specific factors differentiate symptom change in depressed adolescents.Journal of child psychology and psychiatry, and allied disciplines · 2020Trial
- The therapeutic relationship in Cognitive Behaviour Therapy with depressed adolescents: A qualitative study of good-outcome cases.Psychology and psychotherapy · 2020Trial
- Trajectories of depression symptom change during and following treatment in adolescents with unipolar major depression.Journal of child psychology and psychiatry, and allied disciplines · 2020Trial
- How do adolescents with depression experience improvement in psychodynamic psychotherapy? A qualitative study.BMC psychiatry · 2019Trial
- Cognitive Behavioral Therapy Lowers Elevated Functional Connectivity in Depressed Adolescents.EBioMedicine · 2017Trial
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- "Did I bring it on myself?" An exploratory study of the beliefs that adolescents referred to mental health services have about the causes of their depression.European child & adolescent psychiatry · 2017Trial
- Clinical characteristics associated with the prescribing of SSRI medication in adolescents with major unipolar depression.European child & adolescent psychiatry · 2016Trial
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundUp to 70% of adolescents with moderate to severe unipolar major depression respond to psychological treatment plus Fluoxetine (20-50 mg) with symptom reduction and improved social function reported by 24 weeks after beginning treatment. Around 20% of non responders appear treatment resistant and 30% of responders relapse within 2 years. The specific efficacy of different psychological therapies and the moderators and mediators that influence risk for relapse are unclear. The cost-effectiveness and safety of psychological treatments remain poorly evaluated. METHODS/
designImproving Mood with Psychoanalytic and Cognitive Therapies, the IMPACT Study, will determine whether Cognitive Behavioural Therapy or Short Term Psychoanalytic Therapy is superior in reducing relapse compared with Specialist Clinical Care. The study is a multicentre pragmatic effectiveness superiority randomised clinical trial: Cognitive Behavioural Therapy consists of 20 sessions over 30 weeks, Short Term Psychoanalytic Psychotherapy 30 sessions over 30 weeks and Specialist Clinical Care 12 sessions over 20 weeks. We will recruit 540 patients with 180 randomised to each arm. Patients will be reassessed at 6, 12, 36, 52 and 86 weeks. Methodological aspects of the study are systematic recruitment, explicit inclusion criteria, reliability checks of assessments with control for rater shift, research assessors independent of treatment team and blind to randomization, analysis by intention to treat, data management using remote data entry, measures of quality assurance, advanced statistical analysis, manualised treatment protocols, checks of adherence and competence of therapists and assessment of cost-effectiveness. We will also determine whether time to recovery and/or relapse are moderated by variations in brain structure and function and selected genetic and hormone biomarkers taken at entry. DISCUSSION: The objective of this clinical trial is to determine whether there are specific effects of specialist psychotherapy that reduce relapse in unipolar major depression in adolescents and thereby costs of treatment to society. We also anticipate being able to utilise psychotherapy experience, neuroimaging, genetic and hormone measures to reveal what techniques and their protocols may work best for which patients.
trial registrationCurrent Controlled Trials ISRCTN83033550.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.