ArticleNeurogastroenterology and motility2011
Genetic susceptibility to inflammation and colonic transit in lower functional gastrointestinal disorders: preliminary analysis.
Article in Neurogastroenterology and motility, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Pooled it
- Pharmacogenetics in IBS: update and impact of GWAS studies in drug targets and metabolism.Expert opinion on drug metabolism & toxicology · 2024Review
- Gastrointestinal Comorbidities Associated with Atopic Dermatitis-A Narrative Review.International journal of molecular sciences · 2024Review
- Toll-like receptor 4 plays a vital role in irritable bowel syndrome: a scoping review.Frontiers in immunology · 2024Article
- Glucocorticoid receptor-mediatediScience · 2023Article
- Functional gastrointestinal disorders: History taking skills in practice.Clinical medicine (London, England) · 2021Review
- Intestinal barrier dysfunction in irritable bowel syndrome: a systematic review.Therapeutic advances in gastroenterology · 2021Review
- Increased Expression of Toll-Like Receptors 4, 5, and 9 in Small Bowel Mucosa from Patients with Irritable Bowel Syndrome.BioMed research international · 2017Article
- Cannabinoids and GI Disorders: Endogenous and Exogenous.Current treatment options in gastroenterology · 2016Review
- Genetics of irritable bowel syndrome.Molecular and cellular pediatrics · 2016Article
- Genetic polymorphism in pathogenesis of irritable bowel syndrome.World journal of gastroenterology · 2014Review
- Genetic variation in GPBAR1 predisposes to quantitative changes in colonic transit and bile acid excretion.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- Irritable bowel syndrome: emerging paradigm in pathophysiology.World journal of gastroenterology · 2014Review
- Tumor necrosis factor-neuropeptide Y cross talk regulates inflammation, epithelial barrier functions, and colonic motility.Inflammatory bowel diseases · 2013Article
- Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome.American journal of physiology. Gastrointestinal and liver physiology · 2013Review
- Genetics of human gastrointestinal sensation.Neurogastroenterology and motility · 2013Review
- Irritable bowel syndrome: methods, mechanisms, and pathophysiology. Genetic epidemiology and pharmacogenetics in irritable bowel syndrome.American journal of physiology. Gastrointestinal and liver physiology · 2012Review
- Brain-gut axis: from basic understanding to treatment of IBS and related disorders.Journal of pediatric gastroenterology and nutrition · 2012Review
- Orexins stimulate the 'appetite' of the gut.The Journal of physiology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundIrritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) coexist in some patients. We observed an association between Crohn's disease (CD) candidate gene TNFSF15 and IBS symptom phenotype. Three genes (TLR9, IL6, and CDH1) have been associated with postinfectious (PI)-IBS. Our aim was to preliminarily assess association between 30 susceptibility loci for CD, three genes associated with PI-IBS, and PARM1, with colonic transit in lower functional gastrointestinal disorders (FGID).
methodsA cohort of 665 persons was assembled in previous studies. TaqMan assay was used for all single nucleotide polymorphisms (SNPs) associated with the loci of interest. Data were analyzed for univariate associations with symptoms phenotype and colonic transit (nominal P values, uncorrected) using dominant and co-dominant genetic models. KEY
resultsCarriers of the rs5743836 risk allele had increased odds for IBS-D (vs control, P = 0.02, uncorrected). Among the CD risk loci, rs7927894 (P = 0.007), rs7746082 (P=0.011), rs2872507 (P = 0.014), together with rs5743836 (P = 0.010) were univariately associated with colonic transit at 24 or 48 h. Specific tests for genetic interactions between loci revealed potential association of genes that influence neural, barrier, or mast cell function with colonic transit. CONCLUSIONS & INFERENCES: Genetic variations that may influence local mucosal immune functions are univariately associated with altered colonic transit in lower FGID.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.