ArticleOmics : a journal of integrative biology2013
Metabolomics reveals differential levels of oral metabolites in HIV-infected patients: toward novel diagnostic targets.
Article in Omics : a journal of integrative biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 52 citations in OpenAlex.
- Metabolomic profiling reveals alterations in Candida pathophysiology and host interactions during primary oral candidiasis and following antifungal treatment.Scientific reports · 2026Article
- Sample Preparation for Metabolomic Analysis in Exercise Physiology.Biomolecules · 2024Review
- The metabolic consequences of HIV/TB co-infection.BMC infectious diseases · 2023Article
- Plasma metabolomics by nuclear magnetic resonance reveals biomarkers and metabolic pathways associated with the control of HIV-1 infection/progression.Frontiers in molecular biosciences · 2023Article
- The Underrated Salivary Virome of Men Who Have Sex With Men Infected With HIV.Frontiers in immunology · 2021Article
- Metabolomics as a Tool to Investigate HIV/TB Co-Infection.Frontiers in molecular biosciences · 2021Review
- Salivary metabolite levels in perinatally HIV-infected youth with periodontal disease.Metabolomics : Official journal of the Metabolomic Society · 2020Observational
- Single Cell Metabolomics: A Future Tool to Unmask Cellular Heterogeneity and Virus-Host Interaction in Context of Emerging Viral Diseases.Frontiers in microbiology · 2020Review
- Evidence for Proline Utilization by Oral Bacterial Biofilms Grown in Saliva.Frontiers in microbiology · 2020Article
- Immunometabolism is a key factor for the persistent spontaneous elite control of HIV-1 infection.EBioMedicine · 2019Article
- Metabolite changes in blood predict the onset of tuberculosis.Nature communications · 2018Article
- Persistent metabolic changes in HIV-infected patients during the first year of combination antiretroviral therapy.Scientific reports · 2018Article
- Alterations in the oral microbiome in HIV-infected participants after antiretroviral therapy administration are influenced by immune status.AIDS (London, England) · 2018Article
- A baseline metabolomic signature is associated with immunological CD4+ T-cell recovery after 36 months of antiretroviral therapy in HIV-infected patients.AIDS (London, England) · 2018Article
- Examining Relationships between Metabolism and Persistent Inflammation in HIV Patients on Antiretroviral Therapy.Mediators of inflammation · 2018Review
- Recent Trends in System-Scale Integrative Approaches for Discovering Protective Antigens Against Mycobacterial Pathogens.Frontiers in genetics · 2018Review
- Article
- Serum metabolomics analysis of patients with chikungunya and dengue mono/co-infections reveals distinct metabolite signatures in the three disease conditions.Scientific reports · 2016Article
- Correlation of the lung microbiota with metabolic profiles in bronchoalveolar lavage fluid in HIV infection.Microbiome · 2016Article
- Mucosal Regulatory T Cells and T Helper 17 Cells in HIV-Associated Immune Activation.Frontiers in immunology · 2016Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
The objective of the current study was to characterize the profile of oral metabolites in HIV-infected patients using metabolomics. Oral wash samples were collected from 12 HIV-infected and 12 healthy individuals (matched for age, sex, and ethnicity), processed, and analyzed by metabolomics. We detected 198 identifiable and 85 nonidentifiable metabolites; 27 identifiable metabolites were differentially present (12 increased, 15 decreased) in HIV-infected patients. Elevated metabolites included p-cresol sulfate, nucleotides (e.g., allantoin), and amino acids (e.g., phenylalanine, tryptophan), whereas decreased oral metabolites included fucose, fumarate, and N-acetylglucosamine. Pathway network analysis revealed the largest multinode network in healthy versus HIV-infected patients to involve carbohydrate biosynthesis and degradation. HIV-infected patients on antiretroviral therapy (ART) showed the largest number (12) of statistically significant metabolite correlation differences compared with healthy controls. Interestingly, the oral phenlyalanine:tyrosine ratio increased in ART-naive HIV-infected patients (mean ± SEM = 2.58 ± 0.87) compared with healthy individuals (1.33 ± 0.10, p = 0.062) or ART-experienced patients (1.78 ± 0.30, p = 0.441). This is the first study to reveal differential levels of oral metabolites in HIV-infected patients compared withj healthy volunteers, and that oral phenlyalanine:tyrosine ratio may be a useful marker for noninvasive monitoring of the immune status during HIV infection.
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