Evidence map›Paper›PMID 21751402›Full record

ArticleChemMedChem2011

Structure-guided design of a highly selective glycogen synthase kinase-3β inhibitor: a superior neuroprotective pyrazolone showing antimania effects.

Wenwen Chen, Irina N Gaisina, Hendra Gunosewoyo, Sam A Malekiani, Taleen Hanania, Alan P Kozikowski

Abstract read
In one paragraph

Article in ChemMedChem, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wenwen ChenDrug Discovery Program, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood St., Chicago, Illinois 60612, USA.
Irina N Gaisina
Hendra Gunosewoyo
Sam A Malekiani
Taleen Hanania
Alan P Kozikowski

Funding

Molecular Interventions for Bipolar DisorderR01MH079400 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KOZIKOWSKI, ALAN P. · 2007 to 2011
$2.2M
NIMH NIH HHS 1R01 MH072940-01NIMH NIH HHS R01 MH079400
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsBipolar DisorderCell SurvivalDrug DesignGlycogen Synthase Kinase 3Glycogen Synthase Kinase 3 betaHumansNeuroprotective AgentsPyrazolonesRatsStructure-Activity RelationshipGlycogen Synthase Kinase 3Glycogen Synthase Kinase 3 betaGSK3B protein, humanGsk3b protein, ratNeuroprotective AgentspyrazolonePyrazolones

Identifiers

PMID21751402
PMCPMC3428241

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.