Evidence map›Paper›PMID 21751313›Full record

ArticleAngewandte Chemie (International ed. in English)2011

Photo-cross-linkers incorporated into G-protein-coupled receptors in mammalian cells: a ligand comparison.

Irene Coin, Marilyn H Perrin, Wylie W Vale, Lei Wang

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 71 citations in OpenAlex.

  1. Evolutionarily conserved hydrophobicity and sterics in TM3/TM4 balance Orai1 pore opening.Protein science : a publication of the Protein Society · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Genetically encoded crosslinkers to address protein-protein interactions.Protein science : a publication of the Protein Society · 2023
    Review
  13. Orthogonal Crosslinking: A Strategy to Generate Novel Protein Topology and Function.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023
    Article
  14. New covalent bonding ability for proteins.Protein science : a publication of the Protein Society · 2022
    Review
  15. Binding of Natural Peptide Ligands to the Neuropeptide YAngewandte Chemie (International ed. in English) · 2022
    Article
  16. Article
  17. Capturing Peptide-GPCR Interactions and Their Dynamics.Molecules (Basel, Switzerland) · 2020
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Irene CoinJack H. Skirball Center for Chemical Biology and Proteomics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Marilyn H Perrin
Wylie W Vale
Lei Wang
Salk Institute for Biological Studies · US

Funding

Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Reuben Shaw · 1985 to 2026
$82.8M
TARGETED DISRUPTION OF NEUROENDOCRINE GENESP01DK026741 · NIDDK · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI MONTMINY, MARC R · 1986 to 2014
$31.6M
Genetically Encoding Novel Amino Acids to Investigate Wnt Signaling in C. elegansDP2OD004744 · OD · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI WANG, LEI · 2008 to 2009
$3.0M
NCI NIH HHS P30CA014195NIDDK NIH HHS DK026741-31NIDDK NIH HHS P01 DK026741NIH HHS 1DP2OD004744-01NIH HHS DP2 OD004744
6 · The paper itself

Abstract

Capturing the right ligand at the right spot: a well-balanced system for non-natural amino acid mutagenesis allows the ligand binding sites of a class II G-protein coupled receptor to be mapped and distinct binding domains to be identified for different ligands in the native environment of mammalian cells.

Indexed as

LigandsAmino AcidsAnimalsBinding SitesHEK293 CellsHumansMutagenesis, Site-DirectedPhotoaffinity LabelsRatsReceptors, G-Protein-CoupledRecombinant Fusion ProteinsAmino AcidsLigandsPhotoaffinity LabelsReceptors, G-Protein-CoupledRecombinant Fusion Proteins

Identifiers

PMID21751313
PMCPMC3262126
OpenAlexW2143713610

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.