ArticleCancer2012
Management of malignant colonic polyps: a population-based analysis of colonoscopic polypectomy versus surgery.
Article in Cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02328664 (The Sensitivity of Scar-biopsies for Residual Colorectal Adenocarcinoma After Endoscopic Resection With Uncertain Radicality), which is not on this map. Cited by 23 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Sensitivity of Scar-biopsies for Residual Colorectal Adenocarcinoma After Endoscopic Resection With Uncertain Radicality
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Patient and pathological predictors of management strategy for malignant polyps following polypectomy: a systematic review and meta-analysis.International journal of colorectal disease · 2022Pooled it
- Clinical outcome of low- and high-risk malignant colorectal polyps: results of a population-based study and meta-analysis of the available literature.Internal and emergency medicine · 2014Pooled it
- Competing Mortality Redefines the Net Benefit of Additional Surgery After Endoscopic Resection for T1 Colorectal Cancer in Older Adults.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2026Review
- Exploration of between-hospital variation and the basis for decision making in management of malignant colorectal polyps- a Danish population-based study.World journal of surgical oncology · 2026Article
- Significant variation in the assessment and management of screen-detected colorectal polyp cancers.International journal of colorectal disease · 2024Article
- The Role of Tumor Location on Endoscopic and Surgical Management of Malignant Colon Polyps.Annals of surgical oncology · 2024Article
- Approaches and considerations in the endoscopic treatment of T1 colorectal cancer.The Korean journal of internal medicine · 2024Review
- Risk of metastasis and survival in patients undergoing different treatment strategies with T1 colonic neuroendocrine tumors.Journal of endocrinological investigation · 2024Article
- Predictors of early colorectal cancer metastasis to lymph nodes: providing rationale for therapy decisions.Frontiers in oncology · 2024Review
- Weighing the benefits of lymphadenectomy in early-stage colorectal cancer.Annals of surgical treatment and research · 2023Review
- Management of high and low risk malignant polyps: a population-wide analysis.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2023Article
- Factors Predicting Malignant Occurrence and Polyp Recurrence after the Endoscopic Resection of Large Colorectal Polyps: A Single Center Experience.Medicina (Kaunas, Lithuania) · 2022Article
- Article
- Role of Endoscopic Resection Versus Surgical Resection in Management of Malignant Colon Polyps: a National Cancer Database Analysis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2020Article
- Malignant colorectal polyps: endoscopic polypectomy and watchful waiting is not inferior to subsequent bowel resection. A nationwide propensity score-based analysis.Langenbeck's archives of surgery · 2019Article
- Polypectomy versus surgery in early colon cancer: size and location of colon cancer affect long-term survival.International journal of colorectal disease · 2018Article
- Management of Malignant Adenomas.Clinics in colon and rectal surgery · 2015Review
- Screening polypectomy rates below quality benchmarks: a prospective study.World journal of gastroenterology · 2014Observational
- The natural history of colorectal adenomas and early cancer.Der Pathologe · 2012Review
- Additional colectomy after colonoscopic polypectomy for T1 colon cancer: a fine balance between oncologic benefit and operative risk.International journal of colorectal disease · 2012Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe management of colon polyps containing invasive carcinoma includes surgical resection or colonoscopic polypectomy. To date, there are very limited population-based data comparing outcomes with the 2 management approaches.
methodsUsing the linked Surveillance Epidemiology and End Results-Medicare database, we identified 2077 patients aged ≥66 years with an initial diagnosis of stage T1N0M0 malignant polyp from 1992-2005. Patients were categorized as surgical or polypectomy depending on the most invasive treatment. To adjust for potential selection bias in treatment assignment, using multivariate analysis, patients were divided into quintiles of likelihood of polypectomy (propensity scores), and outcomes were compared in each quintile.
resultsSurgical resection was performed in 1340 (64.5%) patients and polypectomy was performed in 737 (35.5%) patients. Predictors for undergoing polypectomy (P<.001) included older age, greater comorbidity, no history of polyps, diagnosis in 2002 or later, left colon site of cancer, well-differentiated tumors, and colonoscopy performed in an outpatient setting. Both 1-year and 5-year survival were higher in the surgical group (92% and 75%, respectively) than in the polypectomy group (88% and 62%, respectively). The unadjusted hazard ratio was 1.51 (95% confidence interval [CI], 1.31-1.74). After adjusting for propensity quintile, the hazard ratio was 1.15 (95% CI, 0.98-1.33). Within each propensity quintile, the risk of death was similar between the 2 groups (interaction test P = .96).
conclusionsIn this large, population-based sample, more than one-third of patients with malignant polyps were treated with colonoscopic polypectomy. Outcomes were similar to surgical patients with comparable clinical characteristics and could be offered to patients who meet appropriate clinical criteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.