ReviewJournal of molecular medicine (Berlin, Germany)2011
The miRNA pathway in neurological and skeletal muscle disease: implications for pathogenesis and therapy.
Review in Journal of molecular medicine (Berlin, Germany), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Circulating miR-144-3p as a Novel Independent Biomarker Associated With Low Muscle Strength Among Older Adults.Journal of cachexia, sarcopenia and muscle · 2025Article
- Biomarkers for intensive care unit-acquired weakness: a systematic review for prediction, diagnosis and prognosis.Annals of intensive care · 2025Review
- Elevated mir-145-5p is associated with skeletal muscle dysfunction and triggers apoptotic cell death in C2C12 myotubes.Journal of muscle research and cell motility · 2022Article
- Editorial: Myokines, Adipokines, Cytokines in Muscle Pathophysiology, Volume II.Frontiers in physiology · 2022Article
- MiR-199-3p enhances muscle regeneration and ameliorates aged muscle and muscular dystrophy.Communications biology · 2021Article
- Delivery of therapeutic oligonucleotides with cell penetrating peptides.Advanced drug delivery reviews · 2015Review
- Increased expression of GDF-15 may mediate ICU-acquired weakness by down-regulating muscle microRNAs.Thorax · 2015Observational
- Intensive Care Foundation Gold Medal Award Presentations.Journal of the Intensive Care Society · 2015Article
- TNF-α and IGF1 modify the microRNA signature in skeletal muscle cell differentiation.Cell communication and signaling : CCS · 2015Article
- Exosome platform for diagnosis and monitoring of traumatic brain injury.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Genomic signatures characterize leukocyte infiltration in myositis muscles.BMC medical genomics · 2012Article
- Novel approaches in the treatment of myositis and myopathies.Therapeutic advances in musculoskeletal disease · 2012Article
- Circulating microRNAs: novel biomarkers for cardiovascular diseases.Journal of molecular medicine (Berlin, Germany) · 2012Review
- Translational control by changes in poly(A) tail length: recycling mRNAs.Nature structural & molecular biology · 2012Review
- Approaches to manipulating microRNAs in neurogenesis.Frontiers in neuroscience · 2012Article
- Select non-coding RNA in blood components provide novel clinically accessible biological surrogates for improved identification of traumatic brain injury in OEF/OIF Veterans.American journal of neurodegenerative disease · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
RNA interference (RNAi) represents a powerful post-transcriptional gene silencing network which fine-tunes gene expression in all eukaryotic cells. The endogenous triggers of RNAi, microRNAs (miRNAs), are proposed to regulate expression of up to a third of all protein-coding genes, and have been shown to have critical roles in developmental processes including in the central nervous system and skeletal muscle. Further, many have been reported to display differential expression in various disease states. Here we describe present understanding of the biogenesis and function of miRNAs, review current knowledge of miRNA abnormalities in both human neurological and skeletal muscle disease and discuss their potential as novel disease biomarkers. Finally, we highlight the many ways in which the miRNA pathway may be targeted for therapeutic benefit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.