ArticleJournal of molecular neuroscience : MN2012
Mice lacking urea transporter UT-B display depression-like behavior.
Article in Journal of molecular neuroscience : MN, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 42 citations in OpenAlex.
- Hotspot pocket-based discovery of urea transporter selective inhibitors.Nature communications · 2026Article
- Early-life adversity induces metabolic alterations in a rodent model of depression: a differential stress response perspective.Acta neuropsychiatrica · 2026Article
- Associations of serum creatinine and blood urea nitrogen with depressive symptoms among community-dwelling older adults in Guangzhou, China: a cross-sectional study.Frontiers in psychiatry · 2026Article
- Urea functions as a risk signal driving astrocyte-mediated neuroinflammation following stroke.Journal of neuroinflammation · 2025Article
- Identification and Validation of Urea Transporter B Inhibitor fromMolecules (Basel, Switzerland) · 2025Article
- The Role of the Urea Cycle in the Alzheimer's Disease Brain.Journal of neurochemistry · 2025Review
- The Role of Preoperative Chronic Hypertension in Neurocognitive Decline after Cardiac Surgery: A Retrospective Cohort Study.Brazilian journal of cardiovascular surgery · 2025Article
- Aging increases UT-B urea transporter protein abundance in brains of male mice.Physiological reports · 2025Article
- Protein Structures of Urea Transporters.Sub-cellular biochemistry · 2025Review
- Physiological Functions of Urea Transporters.Sub-cellular biochemistry · 2025Review
- Modulation of Urea Transport Attenuates TLR2-Mediated Microglial Activation and Upregulates Microglial Metabolism In Vitro.Metabolites · 2024Article
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- Regional investigation of UT-B urea transporters in the rat brain.Biochemistry and biophysics reports · 2023Article
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- Circulating metabolites and depression: a bidirectional Mendelian randomization.Frontiers in neuroscience · 2023Article
- Extensive multiregional urea elevations in a case-control study of vascular dementia point toward a novel shared mechanism of disease amongst the age-related dementias.Frontiers in molecular neuroscience · 2023Article
- Associations between urea nitrogen and risk of depression among subjects with and without type 2 diabetes: A nationwide population-based study.Frontiers in endocrinology · 2022Article
- Inhibition of Urea Transporter (UT)-B Modulates LPS-Induced Inflammatory Responses in BV2 Microglia and N2a Neuroblastoma Cells.Neurochemical research · 2021Article
- Expression of Urea Transporter B in Normal and Injured Brain.Frontiers in neuroanatomy · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Urea transporter B is one of urea transporters that selectively transport urea driven by urea gradient across membrane and expressed abundantly in brain. To determine the physiological role of UT-B in brain, UT-B localization, urea concentration, tissue morphology of brain, and behavioral phenotypes were studied in UT-B heterozygous mice via UT-B null mice. UT-B mRNA was expressed in olfactory bulb, cortex, caudate nucleus, hippocampus and hypothalamus of UT-B heterozygous mice. UT-B null mice exhibited depression-like behavior, with urea accumulation, nitric oxide reduction, and selective neuronal nitric oxide synthase level increase in hippocampus. After acute urea loading, the urea level increased, NO production decreased in hippocampus from both types of mice. Moreover, urea level was higher, and NO concentration was lower consistently in UT-B null hippocampus than that in heterozygous hippocampus. In vitro, 25 mM urea inhibited NO production too. Furthermore, UT-B knockout induced a long-lasting notable decrease in regional cerebral blood flow and altered morphology, such as loss of neurons in CA3 region, swelling, and membranous myelin-like structure formation within myelinated and unmyelinated fibers in hippocampus. These results suggest that urea accumulation in the hippocampus induced by UT-B deletion can cause depression-like behavior, which possibly attribute to disturbance in NOS/NO system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.