ArticleInflammation2012
Elevated expression of β1,4-galactosyltransferase-I in cartilage and synovial tissue of patients with osteoarthritis.
Article in Inflammation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- MicroRNA-15a/β1,4-GalT-I axis contributes to cartilage degeneration via NF-κB signaling in osteoarthritis.Clinics (Sao Paulo, Brazil) · 2023Article
- Galactose Enhances Chondrogenic Differentiation of ATDC5 and Cartilage Matrix Formation by Chondrocytes.Frontiers in molecular biosciences · 2022Article
- Correlation of synovial tissue protein abundance with menopause in osteoarthritis.American journal of translational research · 2022Article
- Identification of key genes in osteoarthritis using bioinformatics, principal component analysis and meta-analysis.Experimental and therapeutic medicine · 2021Article
- Evolution of protein N-glycosylation process in Golgi apparatus which shapes diversity of protein N-glycan structures in plants, animals and fungi.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoarthritis (OA) is considered a complex illness, characterized by cartilage degeneration, secondary synovial membrane inflammation, and subchondral bone sclerosis. Previous studies have shown β1,4-galactosylransferase-I (β1,4-GalT-I) to be a key inflammatory mediator that participates in the initiation and maintenance of inflammatory reaction in diseases. In the present study, we investigated the expression and possible biological function of β1,4-GalT-I in the cartilage and synovial tissue of OA patients. Cartilage and synovial tissue samples from OA patients and healthy controls were stained for β1,4-GalT-I. Reverse transcription-polymerase chain reaction was used to observe the expression of β1,4-GalT-I, and western blot was carried out for E-selectin. The interaction between β1,4-GalT-I and E-selectin was analyzed by double labeling immunohistochemistry and immunoprecipitation. The expression of β1,4-GalT-I increased in the cartilage and synovial tissue of OA patients compared with healthy controls. E-selectin was overexpressed and was correlated with β1,4-GalT-I in OA cartilage and synovial tissue. These data suggest that β1,4-GalT-I may play an important role in the inflammatory processes in cartilage and synovial tissue of patients with OA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.