ArticleDigestive diseases and sciences2011
Smoking and the association of advanced colorectal neoplasia in an asymptomatic average risk population: analysis of exposure and anatomical location in men and women.
Article in Digestive diseases and sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Smoking-associated risks of conventional adenomas and serrated polyps in the colorectum.Cancer causes & control : CCC · 2015Pooled it
- Outcomes and Characteristics Across Age Groups of Patients with Positive MT-sDNA Stool Tests: Data from the New Hampshire Colonoscopy Registry.Digestive diseases and sciences · 2026Article
- Yield of Synchronous Adenomas and Serrated Polyps in Patients With Positive Stool Tests (mt-sDNA or FIT): Data From the New Hampshire Colonoscopy Registry.JGH open : an open access journal of gastroenterology and hepatology · 2026Article
- Why Female Smokers Have Poorer Long-Term Health Outcomes than Male Smokers: The Role of Cigarette Smoking During Pregnancy.Public health reviews · 2024Review
- Young adults and metachronous neoplasia: risks for future advanced adenomas and large serrated polyps compared with older adults.Gastrointestinal endoscopy · 2020Article
- Effect of the thymine-DNA glycosylase rs4135050 variant on Saudi smoker population.Molecular genetics & genomic medicine · 2019Article
- Smoking and Other Risk Factors in Individuals With Synchronous Conventional High-Risk Adenomas and Clinically Significant Serrated Polyps.The American journal of gastroenterology · 2018Article
- Risk factors cannot explain the higher prevalence rates of precancerous colorectal lesions in men.British journal of cancer · 2016Article
- Do recent epidemiologic observations impact who and how we should screen for CRC?Digestive diseases and sciences · 2015Review
- A healthy lifestyle index is associated with reduced risk of colorectal adenomatous polyps among non-users of non-steroidal anti-inflammatory drugs.The journal of primary prevention · 2015Article
- Birthplace is not a determinant of colorectal adenomas.World journal of gastroenterology · 2014Article
- Women and Smoking: The Effect of Gender on the Epidemiology, Health Effects, and Cessation of Smoking.Current addiction reports · 2014Article
- Colorectal carcinogenesis: a cellular response to sustained risk environment.International journal of molecular sciences · 2013Review
- Adenoma Detection Rates for Screening Colonoscopies in Smokers and Obese Adults: Data From the New Hampshire Colonoscopy Registry.Journal of clinical gastroenterologyArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIdentifying risk factors for advanced colorectal adenomas may aid in colorectal cancer (CRC) screening, especially in light of the American College of Gastroenterology's recent guidelines, emphasizing cancer prevention through identification and removal of advanced adenomas. Smoking is an important risk factor for advanced adenomas but there is little data regarding levels of exposure for genders.
methodsThe aim of this study was to use an existing database to examine the genders separately with respect to exposure level and anatomic location of advanced adenomas. Our database was designed to study smoking in an asymptomatic, screening population. Data included demographics, family history of CRC, smoking exposure (pack-years and years smoked), alcohol, diabetes, medications, exercise and dietary history. We excluded patients with a first degree relative with CRC.
resultsCompared to non-smokers, female smokers had an increased risk for advanced adenomas with an exposure of 10-30 pack-years (adjusted odds ratio [AOR] = 4.11; 95% confidence interval [CI], 1.88-9.01) as well as for ≥30 pack-years (AOR = 2.54; 95% CI, 1.08-5.96) while men had an increased risk with smoking ≥30 pack-years (AOR = 3.10; 95% CI, 1.71-5.65). An increased association with smoking was observed for proximal advanced adenomas (AOR = 4.06; 95% CI, 1.62-10.19) and large hyperplastic polyps in women.
conclusionsWomen smokers had an increased risk for advanced adenomas at a lower exposure level and had a greater risk for proximal lesions. These findings may have an impact on CRC screening for women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.