ArticleBiomedical optics express2011
In vivo volumetric imaging of the human corneo-scleral limbus with spectral domain OCT.
Article in Biomedical optics express, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- In Vivo Contactless, Cellular-Resolution Imaging of the Healthy and Pathological Human Limbus With 250-kHz Point-Scanning SD-OCT.Translational vision science & technology · 2024Article
- Diagnostic approach to limbal stem cell deficiency.Frontiers in ophthalmology · 2024Review
- Review
- Diagnostic Algorithm for Surgical Management of Limbal Stem Cell Deficiency.Diagnostics (Basel, Switzerland) · 2023Article
- A Review of the Diagnosis and Treatment of Limbal Stem Cell Deficiency.Frontiers in medicine · 2022Review
- Human limbal epithelial stem cell regulation, bioengineering and function.Progress in retinal and eye research · 2021Review
- Stem Cell Niche Microenvironment: Review.Bioengineering (Basel, Switzerland) · 2021Review
- Limbal stem cell diseases.Experimental eye research · 2021Review
- Fourier-Domain OCT Imaging of the Ocular Surface and Tear Film Dynamics: A Review of the State of the Art and an Integrative Model of the Tear Behavior During the Inter-Blink Period and Visual Fixation.Journal of clinical medicine · 2020Review
- Histological Patterns of Epithelial Alterations in Keratoconus.Journal of ophthalmology · 2020Article
- Accurate tissue interface segmentation via adversarial pre-segmentation of anterior segment OCT images.Biomedical optics express · 2019Article
- Global Consensus on Definition, Classification, Diagnosis, and Staging of Limbal Stem Cell Deficiency.Cornea · 2019Article
- The diagnosis of limbal stem cell deficiency.The ocular surface · 2018Review
- Article
- A method for quantifying limbal stem cell niches using OCT imaging.The British journal of ophthalmology · 2017Article
- Correlation between the existence of the palisades of Vogt and limbal epithelial thickness in limbal stem cell deficiency.Clinical & experimental ophthalmology · 2017Observational
- Ultrahigh-resolution OCT imaging of the human cornea.Biomedical optics express · 2017Article
- In vivo imaging of palisades of Vogt in dry eye versus normal subjects using en-face spectral-domain optical coherence tomography.PloS one · 2017Article
- Estimation of Jones matrix, birefringence and entropy using Cloude-Pottier decomposition in polarization-sensitive optical coherence tomography.Biomedical optics express · 2016Article
- Using optical coherence tomography to assess the role of age and region in corneal epithelium and palisades of vogt.Medicine · 2016Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The limbus is the structurally rich transitional region of tissue between the cornea on one side, and the sclera and conjunctiva on the other. This zone, among other things, contains nerves passing to the cornea, blood and lymph vasculature for oxygen and nutrient delivery and for waste, CO(2) removal and drainage of the aqueous humour. In addition, the limbus contains stem cells responsible for the existence and healing of the corneal epithelium. Here we present 3D images of the healthy human limbus, acquired in vivo with a spectral domain optical coherence tomography system operating at 1060nm. Cross-sectional and volumetric images were acquired from temporal and nasal locations in the human limbus with ~3µm x 18µm (axial x lateral) resolution in biological tissue at the rate of 92,000 A-scans/s. The imaging enabled detailed mapping of the corneo-scleral tissue morphology, and visualization of structural details such as the Vogt palisades, the blood and lymph vasculature including the Schlemm's canal and the trabecular meshwork, as well as corneal nerve fiber bundles. Non-invasive, volumetric, high resolution imaging reveals fine details of the normal human limbal structure, and promises to provide invaluable information about its changes in health and disease as well as during and after corneal surgery.
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