ArticlePloS one2011
Synchrotron radiation micro-CT at the micrometer scale for the analysis of the three-dimensional morphology of microcracks in human trabecular bone.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 80 citations in OpenAlex.
- Advancements in High-Resolution Computed Tomography: Revolutionising Bone Health Micro-Research.Bioengineering (Basel, Switzerland) · 2025Article
- Runaway resorption of microcracks contributes to age-related hip-fracture patients.Scientific reports · 2025Article
- Comparing microCT Staining and Scanning Methodology for Brain Studies in Various Sizes of Spiders.The Journal of comparative neurology · 2025Article
- Biomechanics of the Human Osteochondral Unit: A Systematic Review.Materials (Basel, Switzerland) · 2024Review
- Optimal Agents for Visualizing Collagen Tissue Microarchitecture Using Contrast-Enhanced MicroCT.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Training drives turnover rates in racehorse proximal sesamoid bones.Scientific reports · 2023Article
- Characterizing the Mechanical Behavior of Bone and Bone Surrogates in Compression Using pQCT.Materials (Basel, Switzerland) · 2022Article
- Morphometric measurements can improve prediction of progressive vertebral deformity following vertebral damage.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2022Article
- Review
- Microdamage as a Bone Quality Component: Practical Guidelines for the Two-Dimensional Analysis of Linear Microcracks in Human Cortical Bone.JBMR plus · 2019Review
- Advancements and frontiers in nano-based 3D and 4D scaffolds for bone and cartilage tissue engineering.International journal of nanomedicine · 2019Review
- 3D Imaging of Indentation Damage in Bone.Materials (Basel, Switzerland) · 2018Article
- Long-term effects of bisphosphonate therapy: perforations, microcracks and mechanical properties.Scientific reports · 2017Article
- Techniques to assess bone ultrastructure organization: orientation and arrangement of mineralized collagen fibrils.Journal of the Royal Society, Interface · 2016Review
- Fracture mechanics by three-dimensional crack-tip synchrotron X-ray microscopy.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2015Article
- Modalities for Visualization of Cortical Bone Remodeling: The Past, Present, and Future.Frontiers in endocrinology · 2015Review
- Article
- Prediction of local ultimate strain and toughness of trabecular bone tissue by Raman material composition analysis.BioMed research international · 2015Article
- Non destructive characterization of cortical bone micro-damage by nonlinear resonant ultrasound spectroscopy.PloS one · 2014Article
- Nanoscale examination of microdamage in sheep cortical bone using synchrotron radiation transmission x-ray microscopy.PloS one · 2013Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone quality is an important concept to explain bone fragility in addition to bone mass. Among bone quality factors, microdamage which appears in daily life is thought to have a marked impact on bone strength and plays a major role in the repair process. The starting point for all studies designed to further our understanding of how bone microdamage initiate or dissipate energy, or to investigate the impact of age, gender or disease, remains reliable observation and measurement of microdamage. In this study, 3D Synchrotron Radiation (SR) micro-CT at the micrometric scale was coupled to image analysis for the three-dimensional characterization of bone microdamage in human trabecular bone specimens taken from femoral heads. Specimens were imaged by 3D SR micro-CT with a voxel size of 1.4 µm. A new tailored 3D image analysis technique was developed to segment and quantify microcracks. Microcracks from human trabecular bone were observed in different tomographic sections as well as from 3D renderings. New 3D quantitative measurements on the microcrack density and morphology are reported on five specimens. The 3D microcrack density was found between 3.1 and 9.4/mm3 corresponding to a 2D density between 0.55 and 0.76 /mm2. The microcrack length and width measured in 3D on five selected microcrack ranged respectively from 164 µm to 209 µm and 100 µm to 120 µm. This is the first time that various microcracks in unloaded human trabecular bone--from the simplest linear crack to more complex cross-hatch cracks--have been examined and quantified by 3D imaging at this scale. The suspected complex morphology of microcracks is here considerably more evident than in the 2D observations. In conclusion, this technique opens new perspective for the 3D investigation of microcracks and the impact of age, disease or treatment.
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