ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2011
Genetic association of recovery from eating disorders: the role of GABA receptor SNPs.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Eating Disorders and Parkinson's Disease - 1: Comorbidities, Neurobiology and Family History.medRxiv : the preprint server for health sciences · 2026Article
- Reduced Ventral Tegmental Area GABA neuron output contributes to hyperactivity in the activity-based anorexia model in female mice.Nature communications · 2025Article
- Article
- Pharmacotherapeutic strategies for the treatment of anorexia nervosa - novel targets to break a vicious cycle.Expert opinion on pharmacotherapy · 2024Review
- The multisensory mind: a systematic review of multisensory integration processing in Anorexia and Bulimia Nervosa.Journal of eating disorders · 2023Review
- Inaccessibility of care and inequitable conceptions of suffering: a collective response to the construction of "terminal" anorexia nervosa.Journal of eating disorders · 2023Article
- Gamma-Aminobutyric Acid Type A Receptor Subunit Delta (Iranian journal of public health · 2023Article
- Bibliometric Analysis on GABA-A Receptors Research Based on CiteSpace and VOSviewer.Journal of pain research · 2023Article
- A Clinical Overview of Anorexia Nervosa and Overcoming Treatment Resistance.Avicenna journal of medicine · 2023Review
- Activity-based anorexia animal model: a review of the main neurobiological findings.Journal of eating disorders · 2021Review
- GABAJournal, genetic engineering & biotechnology · 2021Review
- Integrating multi-omics biomarkers and postprandial metabolism to develop personalized treatment for anorexia nervosa.Prostaglandins & other lipid mediators · 2017Article
- Identification of protein-damaging mutations in 10 swine taste receptors and 191 appetite-reward genes.BMC genomics · 2016Article
- Dysregulation of soluble epoxide hydrolase and lipidomic profiles in anorexia nervosa.Molecular psychiatry · 2016Article
- Applying neurobiology to the treatment of adults with anorexia nervosa.Journal of eating disorders · 2016Article
- Altered SPECT (123)I-iomazenil Binding in the Cingulate Cortex of Children with Anorexia Nervosa.Frontiers in psychiatry · 2016Article
- A genome-wide association study of bipolar disorder with comorbid eating disorder replicates the SOX2-OT region.Journal of affective disorders · 2016Article
- Evidence for the role of EPHX2 gene variants in anorexia nervosa.Molecular psychiatry · 2014Article
- Perplexities of treatment resistance in eating disorders.BMC psychiatry · 2013Review
- Nothing tastes as good as skinny feels: the neurobiology of anorexia nervosa.Trends in neurosciences · 2013Review
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Authors and funding
21 authors.
Funding
Abstract
Follow-up studies of eating disorders (EDs) suggest outcomes ranging from recovery to chronic illness or death, but predictors of outcome have not been consistently identified. We tested 5151 single-nucleotide polymorphisms (SNPs) in approximately 350 candidate genes for association with recovery from ED in 1878 women. Initial analyses focused on a strictly defined discovery cohort of women who were over age 25 years, carried a lifetime diagnosis of an ED, and for whom data were available regarding the presence (n=361 ongoing symptoms in the past year, ie, 'ill') or absence (n=115 no symptoms in the past year, ie, 'recovered') of ED symptoms. An intronic SNP (rs17536211) in GABRG1 showed the strongest statistical evidence of association (p=4.63 × 10(-6), false discovery rate (FDR)=0.021, odds ratio (OR)=0.46). We replicated these findings in a more liberally defined cohort of women age 25 years or younger (n=464 ill, n=107 recovered; p=0.0336, OR=0.68; combined sample p=4.57 × 10(-6), FDR=0.0049, OR=0.55). Enrichment analyses revealed that GABA (γ-aminobutyric acid) SNPs were over-represented among SNPs associated at p<0.05 in both the discovery (Z=3.64, p=0.0003) and combined cohorts (Z=2.07, p=0.0388). In follow-up phenomic association analyses with a third independent cohort (n=154 ED cases, n=677 controls), rs17536211 was associated with trait anxiety (p=0.049), suggesting a possible mechanism through which this variant may influence ED outcome. These findings could provide new insights into the development of more effective interventions for the most treatment-resistant patients.
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