ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2011
Presynaptic 5-HT1A is related to 5-HTT receptor density in the human brain.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- A large-scale multimodal investigation of the interplay between the serotonergic system and emotion processing.Translational psychiatry · 2025Trial
- Trial
- Cortico-Striatal-Midbrain Circuit Dysregulation Underlying MK-801 Induced Impulsivity and the Ameliorative Effects of SEP.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The mediation effects of nightmares and depression between insomnia and suicidal ideation in young adults.Scientific reports · 2024Article
- Navigating Like a Fly:International journal of molecular sciences · 2023Review
- Making Sense of Connectivity.The international journal of neuropsychopharmacology · 2019Review
- Potential Mechanism for HIV-Associated Depression: Upregulation of Serotonin Transporters in SIV-Infected Macaques Detected by 11C-DASB PET.Frontiers in psychiatry · 2019Article
- Effect of Citalopram on Emotion Processing in Humans: A Combined 5-HTNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Serotonin 5-HTPeerJ · 2018Article
- Glycosylation States of Pre- and Post-synaptic Markers of 5-HT Neurons Differ With Sex and 5-HTTLPR Genotype in Cortical Autopsy Samples.Frontiers in neuroscience · 2018Article
- A positron emission tomography study of the serotonergic system in relation to anxiety in depression.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2017Article
- Length of axons expressing the serotonin transporter in orbitofrontal cortex is lower with age in depression.Neuroscience · 2017Article
- Serotonin and brain function: a tale of two receptors.Journal of psychopharmacology (Oxford, England) · 2017Review
- Effects of Selective Serotonin Reuptake Inhibitors on Interregional Relation of Serotonin Transporter Availability in Major Depression.Frontiers in human neuroscience · 2017Article
- Lack of association between the serotonin transporter and serotonin 1A receptor: an in vivo PET imaging study in healthy adults.Psychiatry research. Neuroimaging · 2016Article
- Measuring specific receptor binding of a PET radioligand in human brain without pharmacological blockade: The genomic plot.NeuroImage · 2016Article
- Attenuated serotonin transporter association between dorsal raphe and ventral striatum in major depression.Human brain mapping · 2014Article
- The predictive power of brain mRNA mappings for in vivo protein density: a positron emission tomography correlation study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Article
- Mapping neurotransmitter networks with PET: an example on serotonin and opioid systems.Human brain mapping · 2014Article
- A neurobiological hypothesis of treatment-resistant depression - mechanisms for selective serotonin reuptake inhibitor non-efficacy.Frontiers in behavioral neuroscience · 2014Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
5-Hydroxytryptamine (5-HT or serotonin) is an important neurotransmitter for a number of brain functions and widely distributed throughout the brain. Physiological and pharmacological relationship between 5-HT1A receptors and serotonin transporter (5-HTT) in the regulation of 5-HT neurotransmission has now been documented. A relationship between 5-HT1A receptors and 5-HTT is also suggested by the pathophysiology of depression and the mechanism of action of antidepressants. We have scanned 42 healthy adults with both [11C] WAY-100635 and [11C] DASB to investigate the anatomical co-distribution of multiple serotonergic markers. We hypothesized that lower 5-HTT densities in the dorsal raphe nucleus (DRN) and limbic regions will be accompanied by lower 5-HT1A receptor density in the same regions, contributing to the 5-HT1A receptor desensitization. In addition, variations in DRN 5-HT1A receptor density can theoretically influence the density and/or function of other serotonin receptor subtypes and the 5-HTT consequent to changes in serotonergic tone. In a comparatively large sample of volunteers, we have shown that the relationship between 5-HT1A and 5-HTT PET indices was complex. We were unable to demonstrate robust, intra-regional relationships between 5-HT1A and 5-HTT densities. Inter-regionally, DRN 5-HT1A receptors were related to cortical (temporal and frontal regions) and paralimbic (insula), but not limbic 5-HTT. This latter finding may reflect differences in 5-HT tone between individuals, and highlights probable substrates sensitive to variations in DRN 5-HT function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.