ReviewNature reviews. Neurology2011
Depression in epilepsy: a critical review from a clinical perspective.
Review in Nature reviews. Neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Depression in epilepsy: a systematic review and meta-analysis.Neurology · 2013Pooled it
- How Much Difference Does Depression Make to the Outcome of Neuropsychological Assessments of Patients With Epilepsy?European journal of neurology · 2026Article
- Article
- [Saikosaponin a alleviates pentylenetetrazol-induced acute epileptic seizures in mouse models of depression by suppressing microglia activation-mediated inflammation].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024Article
- Association Between Psychiatric Comorbidities and Mortality in Epilepsy.Neurology. Clinical practice · 2021Article
- Epilepsy Associated Depression: An Update on Current Scenario, Suggested Mechanisms, and Opportunities.Neurochemical research · 2021Review
- Recent Studies on Anti-Depressant Bioactive Substances in Selected Species from the GeneraPharmaceuticals (Basel, Switzerland) · 2019Review
- Epilepsy Gene Therapy Using an Engineered Potassium Channel.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Monitoring And Managing Depression In Adolescents With Epilepsy: Current Perspectives.Neuropsychiatric disease and treatment · 2019Article
- Mood disorders in familial epilepsy: A test of shared etiology.Epilepsia · 2018Article
- Antidepressant drug paroxetine blocks the open pore of Kv3.1 potassium channel.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2018Article
- Depression, anxiety, and quality of life in paroxysmal kinesigenic dyskinesia patients.Chinese medical journal · 2017Article
- Mutual associations between intellectual disability and epilepsy-related psychiatry disability: Population-based study.Medicine · 2017Observational
- VEGF-related polymorphisms identified by GWAS and risk for major depression.Translational psychiatry · 2017Article
- Photolysis of Caged-GABA Rapidly Terminates SeizuresFrontiers in neurology · 2017Article
- Mood Disorders in Epilepsy.Focus (American Psychiatric Publishing) · 2016Article
- [Depression and epilepsy : Two clinical pictures with common causes?].Der Nervenarzt · 2016Review
- The Diathesis-Epilepsy Model: How Past Events Impact the Development of Epilepsy and Comorbidities.Cold Spring Harbor perspectives in medicine · 2016Review
- Systemic Family Therapy of Comorbidity of Anxiety and Depression with Epilepsy in Adolescents.Psychiatry investigation · 2016Article
- Antidepressants but not antipsychotics have antiepileptogenic effects with limited effects on comorbid depressive-like behaviour in the WAG/Rij rat model of absence epilepsy.British journal of pharmacology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depression is a serious and frequent comorbidity of epilepsy and other neurological conditions. Here, we review recent studies on the relationship between epilepsy and depression with regard to diagnostic criteria, epidemiology, etiology and treatment. Depression in epilepsy can be described in the general framework of the diathesis-stress model: chronic stress exposure owing to the 'burden of epilepsy' and learned helplessness due to the threat of recurrent seizures as unpredictable aversive events represent psychological risk factors for the development of depression. Epilepsy-related factors (for example, focus site or side) have shown little effect on mood. Nonepileptic individuals who are adversely affected by seizures (for example, parents of pediatric patients with epilepsy, and patients with psychogenic nonepileptic seizures) show increased levels of depression, similar to patients with epilepsy. However, seizures, subclinical hypersynchronous neural discharges and some antiepileptic drugs may cause acute states of depressive mood or depression on a purely neurobiological basis. Antidepressant drugs and psychotherapy have shown moderate efficacy in the treatment of depression comorbidity, but randomized controlled trials in patients with epilepsy are lacking, especially for drugs.
Indexed as
Identifiers
21750525What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.