SynthesisInternational journal of obesity (2005)2012
Implication of European-derived adiposity loci in African Americans.
Synthesis in International journal of obesity (2005), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Transferability and fine mapping of type 2 diabetes loci in African Americans: the Candidate Gene Association Resource Plus Study.Diabetes · 2013Pooled it
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- Common genetic variants associated with obesity in an African-American and Hispanic/Latino population.PloS one · 2021Article
- Interaction between Metabolic Genetic Risk Score and Dietary Fatty Acid Intake on Central Obesity in a Ghanaian Population.Nutrients · 2020Article
- From Bound Cells Comes a Sound Mind: The Role of Neuronal Growth Regulator 1 in Psychiatric Disorders.Experimental neurobiology · 2020Review
- Genetics of Obesity in East Asians.Frontiers in genetics · 2020Review
- Maternal BMI-Increasing Genetic Risk Score and Fetal Weights among Diverse US Ethnic Groups.Obesity (Silver Spring, Md.) · 2019Article
- The association of the fat mass and obesity-associated gene (FTO) rs9939609 polymorphism and the severe obesity in a Brazilian population.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Genome-wide interaction with the insulin secretion locus MTNR1B reveals CMIP as a novel type 2 diabetes susceptibility gene in African Americans.Genetic epidemiology · 2018Article
- The Effect of SH2B1 Variants on Expression of Leptin- and Insulin-Induced Pathways in Murine Hypothalamus.Obesity facts · 2018Article
- Article
- Gene-nutrient interactions and susceptibility to human obesity.Genes & nutrition · 2017Review
- Association of gene coding variation and resting metabolic rate in a multi-ethnic sample of children and adults.BMC obesity · 2017Article
- GENOME-WIDE INTERACTION WITH SELECTED TYPE 2 DIABETES LOCI REVEALS NOVEL LOCI FOR TYPE 2 DIABETES IN AFRICAN AMERICANS.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2017Article
- Association of FTO rs9939609 SNP with Obesity and Obesity- Associated Phenotypes in a North Indian Population.Oman medical journal · 2016Article
- Genome-Wide Interaction with Insulin Secretion Loci Reveals Novel Loci for Type 2 Diabetes in African Americans.PloS one · 2016Article
- Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Obesity-Related Traits.Current diabetes reports · 2015Review
- Progressive influence of body mass index-associated genetic markers in rural Gambians.Journal of medical genetics · 2015Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveRecent genome-wide association studies (GWAS) have identified multiple novel loci associated with adiposity in European-derived study populations. Limited study of these loci has been reported in African Americans. Here we examined the effects of these previously identified adiposity loci in African Americans.
methodsA total of 46 representative single-nucleotide polymorphisms (SNPs) in 19 loci that were previously reported in GWAS in Europeans (including FTO and MC4R) were genotyped in 4992 subjects from six African-American cohorts. These SNPs were tested for association with body mass index (BMI) after adjustment for age, gender, disease status and population structure in each cohort. Meta-analysis was conducted to combine the results.
resultsMeta-analysis of 4992 subjects revealed seven SNPs near four loci, including NEGR1, TMEM18, SH2B1 /ATP2A1 and MC4R, showing significant association at 0.005<P<0.05, and had effect sizes between 0.04 and 0.06 s.d. units (or 0.30 to 0.44 g m(-2)) of BMI for each copy of the BMI-increasing allele. The most significantly associated SNPs (rs9424977, rs3101336 and rs2568958) are located in the NEGR1 gene (P=0.005, 0.020 and 0.019, respectively).
conclusionWe replicated the association of variants at four loci in six African-American cohorts that demonstrated a consistent direction of association with previous studies of adiposity in Europeans. These loci are all highly expressed in the brain, consistent with an important role for central nervous system processes in weight regulation. However, further comprehensive examination of these regions may be necessary to fine map and elucidate for possible genetic differences between these two populations.
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