ReviewNature reviews. Endocrinology2011
Neuropathy in prediabetes: does the clock start ticking early?
Review in Nature reviews. Endocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed, 1 synthesis or guideline pooled it, 218 citations in OpenAlex.
- Effects of Common Polymorphisms in the MTHFR and ACE Genes on Diabetic Peripheral Neuropathy Progression: a Meta-Analysis.Molecular neurobiology · 2017Pooled it
- ARA 290 improves symptoms in patients with sarcoidosis-associated small nerve fiber loss and increases corneal nerve fiber density.Molecular medicine (Cambridge, Mass.) · 2013Trial
- Glucagon-Like Peptide-1 Receptor Agonists: Their Potential Role in Prediabetes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2026Review
- An Electrophysiological Study on the Prevalence of Peripheral Neuropathy in Prediabetics.Cureus · 2026Article
- Risk Factors of Sural Nerve Axonal Degeneration Using Clinically Relevant Thresholds in Context of Glucose Metabolism: The Maastricht Study.Muscle & nerve · 2026Article
- The Natural History of Prediabetes and Cardiovascular Disease in the Pediatric Population.Biomedicines · 2026Review
- Cardiac autonomic neuropathy associated with global metabolic risk status in individuals at risk of type 2 diabetes.Frontiers in endocrinology · 2026Article
- The relationship between neighborhood disadvantage and markers of chronic pain risk: Findings from the Oklahoma Study of Native American Pain Risk (OK-SNAP).The journal of pain · 2025Article
- Identification of pre-diabetes subphenotypes for type 2 diabetes, related vascular complications and mortality.BMJ open diabetes research & care · 2025Article
- Physiological processes induced by different types of physical activity that either oppose or enhance postprandial glucose tolerance.Frontiers in endocrinology · 2025Review
- Characteristics and risk factors associated with developing prediabetes in Saudi Arabia.Annals of medicine · 2024Article
- Article
- Efficacy and safety of glucagon-like peptide-1 receptor agonists on prediabetes: a systematic review and meta-analysis of randomized controlled trials.Diabetology & metabolic syndrome · 2024Article
- Study on risk factors of diabetic peripheral neuropathy and establishment of a prediction model by machine learning.BMC medical informatics and decision making · 2023Article
- Autonomic dysfunction is associated with the development of arterial stiffness: the Whitehall II cohort.GeroScience · 2023Article
- Demographic and Clinical Factors Associated with Depression in 140 Hospitalized Diabetic Patients with Distal Symmetric Polyneuropathy Evaluated Using Beck Depression Inventory and 6-Item Neuropathy Total Symptom Score Questionnaire.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Prediabetes is associated with a higher serum neurofilament light chain level in adolescents.Frontiers in endocrinology · 2023Article
- Clinical Utility of Boston-CTS and Six-Item CTS Questionnaires in Carpal Tunnel Syndrome Associated with Diabetic Polyneuropathy.Diagnostics (Basel, Switzerland) · 2022Article
- A potent physiological method to magnify and sustain soleus oxidative metabolism improves glucose and lipid regulation.iScience · 2022Article
- Relation of glycemic status with unrecognized MI and the subsequent risk of mortality: The Jackson Heart Study.American journal of preventive cardiology · 2022Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Between 25% and 62% of patients with idiopathic peripheral neuropathy are reported to have prediabetes, and among individuals with prediabetes 11-25% are thought to have peripheral neuropathy, and 13-21% have neuropathic pain. Population-based studies suggest a gradient for the prevalence of neuropathy, being highest in patients with manifest diabetes mellitus, followed by individuals with impaired glucose tolerance then impaired fasting glucose and least in those with normoglycemia. The most sensitive test to assess glucose metabolism status is the oral glucose tolerance test. Pathogenesis involves hyperglycemia, microvascular abnormalities, dyslipidemia and the metabolic syndrome. Individuals with prediabetes have less severe neuropathy than those with manifest diabetes mellitus. Sensory modalities are more frequently affected than motor modalities, but impairment of small nerve fibers could be the earliest detectable sign. Diagnosis should rely on careful clinical examination, with emphasis on the evaluation of small fibers. An oral glucose tolerance test should be performed in patients with idiopathic neuropathy. The only treatment with any efficacy is lifestyle modification to improve control of hyperglycemia and cardiovascular risk factors, but long-term efficacy of this approach has not been established. This Review summarizes the current evidence on the association between prediabetes and neuropathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.