ReviewNature reviews. Urology2011
Genetics of innate immunity and UTI susceptibility.
Review in Nature reviews. Urology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 135 citations in OpenAlex.
- UropathogenicAntibiotics (Basel, Switzerland) · 2026Review
- Cocktail of genetically diverse lytic phages reduces uropathogenic Escherichia coli colonization in mouse urinary tract.Scientific reports · 2026Article
- An Overview of the Association of the Urinary Tract Microbiome with Various Diseases and Implications for Therapeutics.Mini reviews in medicinal chemistry · 2025Review
- Urinary tract infections and catheter-associated urinary tract infections caused byMicrobiology and molecular biology reviews : MMBR · 2024Review
- Investigation of TLR4 Polymorphism in Children with Vesicoureteral Reflux and Renal Scarring.Balkan journal of medical genetics : BJMG · 2024Article
- Cataloging the phylogenetic diversity of human bladder bacterial isolates.Genome biology · 2024Article
- Risk factors for recurrent urinary tract infections in young infants under the age of 24 months.Childhood kidney diseases · 2024Article
- Review
- Dynamics of Urinary Extracellular DNA in Urosepsis.Biomolecules · 2023Article
- Review
- Vesicoureteral Reflux and Innate Immune System: Physiology, Physiopathology, and Clinical Aspects.Journal of clinical medicine · 2023Review
- Chronic Kidney Disease-An Underestimated Risk Factor for Antimicrobial Resistance in Patients with Urinary Tract Infections.Biomedicines · 2022Article
- Immunomodulation therapy offers new molecular strategies to treat UTI.Nature reviews. Urology · 2022Review
- YciR, a Specific 3'-Phosphodiesterase, Plays a Role in the Pathogenesis of UropathogenicFrontiers in microbiology · 2022Article
- Molecular determinants of disease severity in urinary tract infection.Nature reviews. Urology · 2021Review
- Sex effects in pyelonephritis.Pediatric nephrology (Berlin, Germany) · 2021Review
- Human microbiome and prostate cancer development: current insights into the prevention and treatment.Frontiers of medicine · 2021Review
- A host receptor enables type 1 pilus-mediated pathogenesis of Escherichia coli pyelonephritis.PLoS pathogens · 2021Article
- Horizontally acquired papGII-containing pathogenicity islands underlie the emergence of invasive uropathogenic Escherichia coli lineages.Nature communications · 2020Article
- Epidemiology, definition and treatment of complicated urinary tract infections.Nature reviews. Urology · 2020Review
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A functional and well-balanced immune response is required to resist most infections. Slight dysfunctions in innate immunity can turn the 'friendly' host defense into an unpleasant foe and give rise to disease. Beneficial and destructive forces of innate immunity have been discovered in the urinary tract and mechanisms by which they influence the severity of urinary tract infections (UTIs) have been elucidated. By modifying specific aspects of the innate immune response to UTI, genetic variation either exaggerates the severity of acute pyelonephritis to include urosepsis and renal scarring or protects against symptomatic disease by suppressing innate immune signaling, as in asymptomatic bacteriuria (ABU). Different genes are polymorphic in patients prone to acute pyelonephritis or ABU, respectively, and yet discussions of UTI susceptibility in clinical practice still focus mainly on social and behavioral factors or dysfunctional voiding. Is it not time for UTIs to enter the era of molecular medicine? Defining why certain individuals are protected from UTI while others have severe, recurrent infections has long been difficult, but progress is now being made, encouraging new approaches to risk assessment and therapy in this large and important patient group, as well as revealing promising facets of 'good' versus 'bad' inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.