ArticlePhysical biology2011
Physics and the canalization of morphogenesis: a grand challenge in organismal biology.
Article in Physical biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Canalization as a stabilizing principle of gene regulatory networks: a discrete dynamical systems perspective.NPJ systems biology and applications · 2026Review
- Neural Organoids, a Versatile Model for Neuroscience.Molecules and cells · 2022Review
- Review
- The developmental-genetics of canalization.Seminars in cell & developmental biology · 2019Review
- The noisy basis of morphogenesis: Mechanisms and mechanics of cell sheet folding inferred from developmental variability.PLoS biology · 2018Article
- Using cell deformation and motion to predict forces and collective behavior in morphogenesis.Seminars in cell & developmental biology · 2017Review
- Mechanics of neurulation: From classical to current perspectives on the physical mechanics that shape, fold, and form the neural tube.Birth defects research · 2017Review
- Top-down models in biology: explanation and control of complex living systems above the molecular level.Journal of the Royal Society, Interface · 2016Review
- Capabilities and Limitations of Tissue Size Control through Passive Mechanical Forces.PLoS computational biology · 2015Article
- Re-membering the body: applications of computational neuroscience to the top-down control of regeneration of limbs and other complex organs.Integrative biology : quantitative biosciences from nano to macro · 2015Review
- Gap Junctional Blockade Stochastically Induces Different Species-Specific Head Anatomies in Genetically Wild-Type Girardia dorotocephala Flatworms.International journal of molecular sciences · 2015Article
- Molecular bioelectricity: how endogenous voltage potentials control cell behavior and instruct pattern regulation in vivo.Molecular biology of the cell · 2014Article
- Endogenous bioelectrical networks store non-genetic patterning information during development and regeneration.The Journal of physiology · 2014Review
- Contractile and mechanical properties of epithelia with perturbed actomyosin dynamics.PloS one · 2014Article
- Biomechanics and the thermotolerance of development.PloS one · 2014Article
- The maternal-to-zygotic transition targets actin to promote robustness during morphogenesis.PLoS genetics · 2013Article
- The interplay between cell signalling and mechanics in developmental processes.Nature reviews. Genetics · 2013Review
- On the role of intrinsic and extrinsic forces in early cardiac S-looping.Developmental dynamics : an official publication of the American Association of Anatomists · 2013Article
- Physiological inputs regulate species-specific anatomy during embryogenesis and regeneration.Communicative & integrative biologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Morphogenesis takes place against a background of organism-to-organism and environmental variation. Therefore, fundamental questions in the study of morphogenesis include: How are the mechanical processes of tissue movement and deformation affected by that variability, and in turn, how do the mechanic of the system modulate phenotypic variation? We highlight a few key factors, including environmental temperature, embryo size and environmental chemistry that might perturb the mechanics of morphogenesis in natural populations. Then we discuss several ways in which mechanics-including feedback from mechanical cues-might influence intra-specific variation in morphogenesis. To understand morphogenesis it will be necessary to consider whole-organism, environment and evolutionary scales because these larger scales present the challenges that developmental mechanisms have evolved to cope with. Studying the variation organisms express and the variation organisms experience will aid in deciphering the causes of birth defects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.