ArticleGenetics2011
Genetic dissection of a key reproductive barrier between nascent species of house mice.
Article in Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 88 citations in OpenAlex.
- Beyond the Prdm9 model: independent evolution of hybrid male sterility in house mice.Heredity · 2026Article
- Population Genomics of Giant Mice from the Faroe Islands: Hybridization, Colonization, and a Novel Challenge to Identifying Genomic Targets of Selection.Genome biology and evolution · 2025Article
- Do genetic loci that cause reproductive isolation in the lab inhibit gene flow in nature?Evolution; international journal of organic evolution · 2024Article
- Inference of selective forces on house mouse genomes during secondary contact in East Asia.Genome research · 2024Article
- Meiotic Recognition of Evolutionarily Diverged Homologs: Chromosomal Hybrid Sterility Revisited.Molecular biology and evolution · 2023Article
- Genic and chromosomal components of Prdm9-driven hybrid male sterility in mice (Mus musculus).Genetics · 2022Article
- Insights into Mus musculus Population Structure across Eurasia Revealed by Whole-Genome Analysis.Genome biology and evolution · 2022Article
- Stage-specific disruption of X chromosome expression during spermatogenesis in sterile house mouse hybrids.G3 (Bethesda, Md.) · 2022Article
- Altering the Binding Properties of PRDM9 Partially Restores Fertility across the Species Boundary.Molecular biology and evolution · 2021Article
- Prdm9 Intersubspecific Interactions in Hybrid Male Sterility of House Mouse.Molecular biology and evolution · 2020Article
- Characterization of black spot resistance in diploid roses with QTL detection, meta-analysis and candidate-gene identification.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Article
- Article
- Further resolution of the house mouse (Mus musculus) phylogeny by integration over isolation-with-migration histories.BMC evolutionary biology · 2020Article
- Disrupted Gene Networks in Subfertile Hybrid House Mice.Molecular biology and evolution · 2020Article
- Phenotypic effects of the Y chromosome are variable and structured in hybrids among house mouse recombinant lines.Ecology and evolution · 2019Article
- A high-throughput method for unbiased quantitation and categorization of nuclear morphology†.Biology of reproduction · 2019Article
- Hybrid Sterility with Meiotic Metaphase Arrest in Intersubspecific Mouse Crosses.The Journal of heredity · 2019Article
- Article
- Coadapted genomes and selection on hybrids: Fisher's geometric model explains a variety of empirical patterns.Evolution letters · 2018Article
- Speciation genes are more likely to have discordant gene trees.Evolution letters · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Reproductive isolation between species is often caused by deleterious interactions among loci in hybrids. Finding the genes involved in these incompatibilities provides insight into the mechanisms of speciation. With recently diverged subspecies, house mice provide a powerful system for understanding the genetics of reproductive isolation early in the speciation process. Although previous studies have yielded important clues about the genetics of hybrid male sterility in house mice, they have been restricted to F1 sterility or incompatibilities involving the X chromosome. To provide a more complete characterization of this key reproductive barrier, we conducted an F2 intercross between wild-derived inbred strains from two subspecies of house mice, Mus musculus musculus and Mus musculus domesticus. We identified a suite of autosomal and X-linked QTL that underlie measures of hybrid male sterility, including testis weight, sperm density, and sperm morphology. In many cases, the autosomal loci were unique to a specific sterility trait and exhibited an effect only when homozygous, underscoring the importance of examining reproductive barriers beyond the F1 generation. We also found novel two-locus incompatibilities between the M. m. musculus X chromosome and M. m. domesticus autosomal alleles. Our results reveal a complex genetic architecture for hybrid male sterility and suggest a prominent role for reproductive barriers in advanced generations in maintaining subspecies integrity in house mice.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.