ArticleGenetics2011
Massive changes in genome architecture accompany the transition to self-fertility in the filamentous fungus Neurospora tetrasperma.
Article in Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 74 citations in OpenAlex.
- Stepwise recombination suppression around the mating-type locus in an ascomycete fungus with self-fertile spores.PLoS genetics · 2023Article
- Nuclear-specific gene expression in heterokaryons of the filamentous ascomyceteProceedings. Biological sciences · 2022Article
- FunOrder: A robust and semi-automated method for the identification of essential biosynthetic genes through computational molecular co-evolution.PLoS computational biology · 2021Article
- Genomic diversity, chromosomal rearrangements, and interspecies hybridization in the Ogataea polymorpha species complex.G3 (Bethesda, Md.) · 2021Article
- Recombination suppression and evolutionary strata around mating-type loci in fungi: documenting patterns and understanding evolutionary and mechanistic causes.The New phytologist · 2021Review
- Occurrence and possible roles of polysaccharides in fungi and their influence on the development of new technologies.Carbohydrate polymers · 2020Review
- Comparative analysis of genome-wide DNA methylation inEpigenetics · 2020Article
- Genomic Features ofPathogens (Basel, Switzerland) · 2020Article
- Genome-Wide Analyses of Repeat-Induced Point Mutations in the Ascomycota.Frontiers in microbiology · 2020Article
- Repeat-Induced Point Mutations Drive Divergence betweenPathogens (Basel, Switzerland) · 2019Article
- Programmed Cell Death inGenetics · 2019Article
- Evolution and functional characterization of pectate lyase PEL12, a member of a highly expanded Clonostachys rosea polysaccharide lyase 1 family.BMC microbiology · 2018Article
- Convergent evolution of complex genomic rearrangements in two fungal meiotic drive elements.Nature communications · 2018Article
- Evolution of recombination rates between sex chromosomes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Large-scale suppression of recombination predates genomic rearrangements in Neurospora tetrasperma.Nature communications · 2017Article
- Genomic structure and evolution of the mating type locus in the green seaweed Ulva partita.Scientific reports · 2017Article
- A-to-I RNA editing is developmentally regulated and generally adaptive for sexual reproduction inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Sources of Fungal Genetic Variation and Associating It with Phenotypic Diversity.Microbiology spectrum · 2017Review
- Diverse data supports the transition of filamentous fungal model organisms into the post-genomics era.Mycology · 2017Article
- OcculterCut: A Comprehensive Survey of AT-Rich Regions in Fungal Genomes.Genome biology and evolution · 2016Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
A large region of suppressed recombination surrounds the sex-determining locus of the self-fertile fungus Neurospora tetrasperma. This region encompasses nearly one-fifth of the N. tetrasperma genome and suppression of recombination is necessary for self-fertility. The similarity of the N. tetrasperma mating chromosome to plant and animal sex chromosomes and its recent origin (<5 MYA), combined with a long history of genetic and cytological research, make this fungus an ideal model for studying the evolutionary consequences of suppressed recombination. Here we compare genome sequences from two N. tetrasperma strains of opposite mating type to determine whether structural rearrangements are associated with the nonrecombining region and to examine the effect of suppressed recombination for the evolution of the genes within it. We find a series of three inversions encompassing the majority of the region of suppressed recombination and provide evidence for two different types of rearrangement mechanisms: the recently proposed mechanism of inversion via staggered single-strand breaks as well as ectopic recombination between transposable elements. In addition, we show that the N. tetrasperma mat a mating-type region appears to be accumulating deleterious substitutions at a faster rate than the other mating type (mat A) and thus may be in the early stages of degeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.