ArticlePhysiological genomics2011
Impact of aging vs. estrogen loss on cardiac gene expression: estrogen replacement and inflammation.
Article in Physiological genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Estrogen Receptor Functions and Pathways at the Vascular Immune Interface.International journal of molecular sciences · 2021Review
- Estrogen, Angiogenesis, Immunity and Cell Metabolism: Solving the Puzzle.International journal of molecular sciences · 2018Review
- Cardiomyocyte-specific deletion of the G protein-coupled estrogen receptor (GPER) leads to left ventricular dysfunction and adverse remodeling: A sex-specific gene profiling analysis.Biochimica et biophysica acta. Molecular basis of disease · 2017Article
- Estrogen receptor antagonism exacerbates cardiac structural and functional remodeling in female rats.American journal of physiology. Heart and circulatory physiology · 2017Article
- Mast Cell Inhibition Attenuates Cardiac Remodeling and Diastolic Dysfunction in Middle-aged, Ovariectomized Fischer 344 × Brown Norway Rats.Journal of cardiovascular pharmacology · 2016Article
- 11,12-Epoxyecosatrienoic acids mitigate endothelial dysfunction associated with estrogen loss and aging: Role of membrane depolarization.Journal of molecular and cellular cardiology · 2016Article
- The Expanding Complexity of Estrogen Receptor Signaling in the Cardiovascular System.Circulation research · 2016Review
- Methanolic Extract of Ceplukan Leaf (Physalis minima L.) Attenuates Ventricular Fibrosis through Inhibition of TNF-α in Ovariectomized Rats.Advances in pharmacological sciences · 2016Article
- Estrogen effects on vascular inflammation are age dependent: role of estrogen receptors.Arteriosclerosis, thrombosis, and vascular biology · 2014Article
- Estrogen and the female heart.Molecular and cellular endocrinology · 2014Review
- Role of estrogen in diastolic dysfunction.American journal of physiology. Heart and circulatory physiology · 2014Review
- Antioxidative effect of aspirin on vascular function of aged ovariectomized rats.Age (Dordrecht, Netherlands) · 2014Article
- Estrogen therapy, independent of timing, improves cardiac structure and function in oophorectomized mRen2.Lewis rats.Menopause (New York, N.Y.) · 2013Article
- Impact of endothelial microparticles on coagulation, inflammation, and angiogenesis in age-related vascular diseases.Journal of aging research · 2013Review
- Aging, estrogen loss and epoxyeicosatrienoic acids (EETs).PloS one · 2013Article
- Identification of estrogen responsive genes using esophageal squamous cell carcinoma (ESCC) as a model.BMC systems biology · 2012Article
- Estrogen and the cardiovascular system.Pharmacology & therapeutics · 2012Review
- Estrogenic modulation of inflammation-related genes in male rats following volume overload.Physiological genomics · 2012Article
- Vascular Aging in Women: is Estrogen the Fountain of Youth?Frontiers in physiology · 2012Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
Despite an abundance of evidence to the contrary from animal studies, large clinical trials on humans have shown that estrogen administered to postmenopausal women increases the risk of cardiovascular disease. However, timing may be everything, as estrogen is often administered immediately after ovariectomy (Ovx) in animal studies, while estrogen administration in human studies occurred many years postmenopause. This study investigates the discrepancy by administering 17β-estradiol (E2) in a slow-release capsule to Norway Brown rats both immediately following Ovx and 9 wk post-Ovx (Late), and studying differences in gene expression between these two groups compared with age-matched Ovx and sham-operated animals. Two different types of microarray were used to analyze the left ventricles from these groups: an Affymetrix array (n = 3/group) and an inflammatory cytokines and receptors PCR array (n = 4/group). Key genes were analyzed by Western blotting. Ovx without replacement led to an increase in caspase 3, caspase 9, calpain 2, matrix metalloproteinase (MMP)9, and TNF-α. Caspase 6, STAT3, and CD11b increased in the Late group, while tissue inhibitor of metalloproteinase 2, MMP14, and collagen I α1 were decreased. MADD and fibronectin were increased in both Ovx and Late. TNF-α and inducible nitric oxide synthase (iNOS) protein levels increased with Late replacement. Many of these changes were prevented by early E2 replacement. These findings suggest that increased expression of inflammatory genes, such as TNF-α and iNOS, may be involved in some of the deleterious effects of delayed E2 administration seen in human studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.