ArticleDevelopment (Cambridge, England)2011
Fgf differentially controls cross-antagonism between cardiac and haemangioblast regulators.
Article in Development (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 48 citations in OpenAlex.
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- Endocardial identity is established during early somitogenesis by Bmp signalling acting upstream of npas4l and etv2.Development (Cambridge, England) · 2022Article
- From Stripes to a Beating Heart: Early Cardiac Development in Zebrafish.Journal of cardiovascular development and disease · 2021Review
- Pathways Regulating Establishment and Maintenance of Cardiac Chamber Identity in Zebrafish.Journal of cardiovascular development and disease · 2021Review
- Activating transcription factor 3 coordinates differentiation of cardiac and hematopoietic progenitors by regulating glucose metabolism.Science advances · 2020Article
- Review
- A High-Content Screen Reveals New Small-Molecule Enhancers of Ras/Mapk Signaling as Probes for Zebrafish Heart Development.Molecules (Basel, Switzerland) · 2018Article
- Continuous addition of progenitors forms the cardiac ventricle in zebrafish.Nature communications · 2018Article
- Physiological Responses to Swimming-Induced Exercise in the Adult Zebrafish Regenerating Heart.Frontiers in physiology · 2018Article
- Etv2 as an essential regulator of mesodermal lineage development.Cardiovascular research · 2017Review
- FGF signaling enforces cardiac chamber identity in the developing ventricle.Development (Cambridge, England) · 2017Article
- Dynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation.Developmental cell · 2016Article
- The ETS Factor, ETV2: a Master Regulator for Vascular Endothelial Cell Development.Molecules and cells · 2015Review
- An early requirement for nkx2.5 ensures the first and second heart field ventricular identity and cardiac function into adulthood.Developmental biology · 2015Article
- Direct nkx2-5 transcriptional repression of isl1 controls cardiomyocyte subtype identity.Stem cells (Dayton, Ohio) · 2015Article
- A novel TGFβ modulator that uncouples R-Smad/I-Smad-mediated negative feedback from R-Smad/ligand-driven positive feedback.PLoS biology · 2015Article
- Genetic networks governing heart development.Cold Spring Harbor perspectives in medicine · 2014Review
- In vivo structure-activity relationship studies support allosteric targeting of a dual specificity phosphatase.Chembiochem : a European journal of chemical biology · 2014Article
- Coordinated repression and activation of two transcriptional programs stabilizes cell fate during myogenesis.Development (Cambridge, England) · 2014Article
- Heart genetics in a small package, exploiting the condensed genome of Ciona intestinalis.Briefings in functional genomics · 2014Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Fibroblast growth factor (Fgf) has been implicated in the control of heart size during development, although whether this is by controlling cell fate, survival or proliferation has not been clear. Here, we show that Fgf, without affecting survival or proliferation, acts during gastrulation to drive cardiac fate and restrict anterior haemangioblast fate in zebrafish embryos. The haemangioblast programme was thought to be activated before the cardiac programme and is repressive towards it, suggesting that activation by Fgf of the cardiac programme might be via suppression of the haemangioblast programme. However, we show that the cardiac regulator nkx2.5 can also repress the haemangioblast programme and, furthermore, that cardiac specification still requires Fgf signalling even when haemangioblast regulators are independently suppressed. We further show that nkx2.5 and the cloche candidate gene lycat are expressed during gastrulation and regulated by Fgf, and that nkx2.5 overexpression, together with loss of the lycat targets etsrp and scl can stably induce expansion of the heart. We conclude that Fgf controls cardiac and haemangioblast fates by the simultaneous regulation of haemangioblast and cardiac regulators. We propose that elevation of Fgf signalling in the anterior haemangioblast territory could have led to its recruitment into the heart field during evolution, increasing the size of the heart.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.