ArticleDevelopment (Cambridge, England)2011
Bone morphogenetic proteins regulate neural tube closure by interacting with the apicobasal polarity pathway.
Article in Development (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 69 citations in OpenAlex.
- Reciprocal coupling between EMT and BMP morphogen signalling drives collective cell invasion.The EMBO journal · 2026Article
- The Critical Role of YAP/BMP/ID1 Axis on Simulated Microgravity-Induced Neural Tube Defects in Human Brain Organoids.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Spatiotemporal Characterization of Human Early Intervertebral Disc Formation at Single-Cell Resolution.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Loss-of-Function of p21-Activated Kinase 2 Links BMP Signaling to Neural Tube Patterning Defects.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- TMEM132A ensures mouse caudal neural tube closure and regulates integrin-based mesodermal migration.Development (Cambridge, England) · 2022Article
- Local BMP signaling: A sensor for synaptic activity that balances synapse growth and function.Current topics in developmental biology · 2022Review
- Supercritical fluid extract ofFrontiers in pharmacology · 2022Article
- A Micropatterned Human-Specific Neuroepithelial Tissue for Modeling Gene and Drug-Induced Neurodevelopmental Defects.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Sonic hedgehog signaling directs patterned cell remodeling during cranial neural tube closure.eLife · 2020Article
- Selective Disruption of Synaptic BMP Signaling by a Smad Mutation Adjacent to the Highly Conserved H2 Helix.Genetics · 2020Article
- Polarity Establishment and Maintenance in Ascidian Notochord.Frontiers in cell and developmental biology · 2020Review
- The cellular bases of choroid fissure formation and closure.Developmental biology · 2018Article
- Folate action in nervous system development and disease.Developmental neurobiology · 2018Review
- Morphogenetic defects underlie Superior Coloboma, a newly identified closure disorder of the dorsal eye.PLoS genetics · 2018Article
- Folate receptor 1 is necessary for neural plate cell apical constriction duringDevelopment (Cambridge, England) · 2017Article
- Neural tube closure: cellular, molecular and biomechanical mechanisms.Development (Cambridge, England) · 2017Review
- G-protein-coupled receptor signaling and neural tube closure defects.Birth defects research · 2017Review
- Cell-cycle-dependent TGFβ-BMP antagonism regulates neural tube closure by modulating tight junctions.Journal of cell science · 2017Article
- Prkci is required for a non-autonomous signal that coordinates cell polarity during cavitation.Developmental biology · 2016Article
- Thyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assembly.Development (Cambridge, England) · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During neural tube closure, specialized regions called hinge points (HPs) display dynamic and polarized cell behaviors necessary for converting the neural plate into a neural tube. The molecular bases of such cell behaviors (e.g. apical constriction, basal nuclear migration) are poorly understood. We have identified a two-dimensional canonical BMP activity gradient in the chick neural plate that results in low and temporally pulsed BMP activity at the ventral midline/median hinge point (MHP). Using in vivo manipulations, high-resolution imaging and biochemical analyses, we show that BMP attenuation is necessary and sufficient for MHP formation. Conversely, BMP overexpression abolishes MHP formation and prevents neural tube closure. We provide evidence that BMP modulation directs neural tube closure via the regulation of apicobasal polarity. First, BMP blockade produces partially polarized neural cells, which retain contact with the apical and basal surfaces but where basolateral proteins (LGL) become apically localized and apical junctional proteins (PAR3, ZO1) become targeted to endosomes. Second, direct LGL misexpression induces ectopic HPs identical to those produced by noggin or dominant-negative BMPR1A. Third, BMP-dependent biochemical interactions occur between the PAR3-PAR6-aPKC polarity complex and phosphorylated SMAD5 at apical junctions. Finally, partially polarized cells normally occur at the MHP, their frequencies inversely correlated with the BMP activity gradient in the neural plate. We propose that spatiotemporal modulation of the two-dimensional BMP gradient transiently alters cell polarity in targeted neuronal cells. This ensures that the neural plate is flexible enough to be focally bent and shaped into a neural tube, while retaining overall epithelial integrity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.