Evidence map›Paper›PMID 21749974›Full record

ArticleAmerican journal of epidemiology2011

The PhenX Toolkit: get the most from your measures.

Carol M Hamilton, Lisa C Strader, Joseph G Pratt, Deborah Maiese, Tabitha Hendershot, Richard K Kwok, Jane A Hammond, Wayne Huggins, Dean Jackman, Huaqin Pan and 14 more

5 registry-linked trialsAbstract read
In one paragraph

Article in American journal of epidemiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 585 papers.

0numbers the graph read from it
0cells of the map it votes in
585citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06733584 narecruitingnot on this mapstarted 2025, after this paper: background citation

Meeting the Needs of Young Hispanic Autistic Children: Developing a Culturally and Linguistically Sensitive Intervention to Alleviate Core Social Challenges

TypeinterventionalSponsorThe University of Texas at DallasRan2025 to 2028Enrolled200ConditionsAutismArmsCulturally and Linguistically Responsive Pathways Parent-Mediated Intervention without Mutual Gaze, Culturally and Linguistically Responsive Pathways Parent-Mediated Intervention
NCT06773299 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

ENhancing Intergenerational HeAlth in Nigeria: Peripartum as Critical Life StagE for CardioVascular Health

TypeinterventionalSponsorWashington University School of MedicineRan2025 to 2028Enrolled1,000ConditionsHypertension in Pregnancy, Hypertension, Obesity and Overweight, Maternal Morbidity and MortalityArmsPAT+HEALTH curriculum - Nigeria
NCT06837181 recruitingnot on this mapstarted 2025, after this paper: background citation

Studying the Presence of CFRD Complications With Thoughtful Recruitment (SPeCTRuM)

TypeobservationalSponsorJaeb Center for Health ResearchRan2025 to 2028Enrolled200ConditionsCystic Fibrosis (CF), Cystic Fibrosis-related Diabetes, Diabetes, RetinopathyArmsobservational study
NCT07599475 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Boosting Brain and Balance: A Mobile Dual-Task Intervention for Athletes With Concussion and Mild Traumatic Brain Injury (mTBI)

TypeinterventionalSponsorHyunhwa LeeRan2026 to 2027Enrolled20ConditionsMild Traumatic Brain Injury (mTBI), Sports-related Concussion, Heart Rate Variability (HRV), WalkingArmsHome-Based Mobile Dual-Task Intervention (BraW-Day™)
NCT07699159 recruitingnot on this mapstarted 2025, after this paper: background citation

Cohort Network for Adolescents and Youth With multipLe Mental Health Conditions (CALM): A Master Observational Trial

TypeobservationalSponsorCentre for Addiction and Mental HealthRan2025 to 2028Enrolled1,620ConditionsMultiple Mental Health Conditions, Child Mental Health, Youth Mental Health
3 · Its place in the literature

Who cites it

585 citing papers in PubMed.

  1. Trial
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  9. Effects of a Tailored Mobile Messaging Intervention for Indoor Tanning Cessation in Young Females: A Randomized Clinical Trial.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
    Trial
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  12. Article
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  18. Review
  19. Article
  20. Article

525 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Carol M HamiltonRTI International, Research Triangle Park, North Carolina 27709, USA. chamilton@rti.org
Lisa C Strader
Joseph G Pratt
Deborah Maiese
Tabitha Hendershot
Richard K Kwok
Jane A Hammond
Wayne Huggins
Dean Jackman
Huaqin Pan
Destiney S Nettles
Terri H Beaty
Lindsay A Farrer
Peter Kraft
Mary L Marazita
Jose M Ordovas
Carlos N Pato
Margaret R Spitz
Diane Wagener
Michelle Williams
Heather A Junkins
William R Harlan
Erin M Ramos
Jonathan Haines

Funding

Building Consensus for Standard Measures for Genome-Wide Association StudiesU01HG004597 · NHGRI · RESEARCH TRIANGLE INSTITUTE · PI HAMILTON, CAROL MARIE · 2007 to 2012
$11.1M
NHGRI NIH HHS U01 HG004597NHGRI NIH HHS U01 HG004597-01
6 · The paper itself

Abstract

The potential for genome-wide association studies to relate phenotypes to specific genetic variation is greatly increased when data can be combined or compared across multiple studies. To facilitate replication and validation across studies, RTI International (Research Triangle Park, North Carolina) and the National Human Genome Research Institute (Bethesda, Maryland) are collaborating on the consensus measures for Phenotypes and eXposures (PhenX) project. The goal of PhenX is to identify 15 high-priority, well-established, and broadly applicable measures for each of 21 research domains. PhenX measures are selected by working groups of domain experts using a consensus process that includes input from the scientific community. The selected measures are then made freely available to the scientific community via the PhenX Toolkit. Thus, the PhenX Toolkit provides the research community with a core set of high-quality, well-established, low-burden measures intended for use in large-scale genomic studies. PhenX measures will have the most impact when included at the experimental design stage. The PhenX Toolkit also includes links to standards and resources in an effort to facilitate data harmonization to legacy data. Broad acceptance and use of PhenX measures will promote cross-study comparisons to increase statistical power for identifying and replicating variants associated with complex diseases and with gene-gene and gene-environment interactions.

Indexed as

Computational BiologyGenome, HumanGenome-Wide Association StudyGenomicsGenotypeHumansInformation DisseminationInternetPhenotypePolymorphism, GeneticReference Standards

Identifiers

PMID21749974
PMCPMC3141081

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.