ArticleEmerging infectious diseases2011
Multiple introductions of multidrug-resistant tuberculosis into households, Lima, Peru.
Article in Emerging infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Environmental health recommendations for Multidrug-Resistant Tuberculosis in low- and middle-income countries: a systematic review.BMC public health · 2026Pooled it
- Investigating the intensity of social contacts associated with tuberculosis: a weighted networks model.BMC pulmonary medicine · 2023Article
- Dysglycemia is associated with Mycobacterium tuberculosis lineages in tuberculosis patients of North Lima-Peru.PloS one · 2021Article
- A Case-Control Study to Identify Community Venues Associated with Genetically-clustered, Multidrug-resistant Tuberculosis Disease in Lima, Peru.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Article
- Investigating spillover of multidrug-resistant tuberculosis from a prison: a spatial and molecular epidemiological analysis.BMC medicine · 2018Article
- Extensions to Bayesian generalized linear mixed effects models for household tuberculosis transmission.Statistics in medicine · 2017Article
- Predictors of multidrug resistant tuberculosis among adult patients at Saint Peter Hospital Addis Ababa, Ethiopia.The Pan African medical journal · 2016Article
- Fitness Costs of Drug Resistance Mutations in Multidrug-Resistant Mycobacterium tuberculosis: A Household-Based Case-Control Study.The Journal of infectious diseases · 2016Article
- Transmission of Multidrug-Resistant and Drug-Susceptible Tuberculosis within Households: A Prospective Cohort Study.PLoS medicine · 2015Article
- Predominant Mycobacterium tuberculosis Families and High Rates of Recent Transmission among New Cases Are Not Associated with Primary Multidrug Resistance in Lima, Peru.Journal of clinical microbiology · 2015Article
- Evolution and transmission patterns of extensively drug-resistant tuberculosis in China.Antimicrobial agents and chemotherapy · 2015Article
- Article
- Clinical outcomes among persons with pulmonary tuberculosis caused by Mycobacterium tuberculosis isolates with phenotypic heterogeneity in results of drug-susceptibility tests.The Journal of infectious diseases · 2014Article
- Concordance of resistance profiles in households of patients with multidrug-resistant tuberculosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2014Article
- Genetic variability of Mycobacterium tuberculosis complex in patients with no known risk factors for MDR-TB in the North-Eastern part of Lima, Peru.BMC infectious diseases · 2013Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Two cases of multidrug-resistant tuberculosis (MDR TB) in a household are assumed to reflect within-household transmission. However, in high-incidence areas of MDR TB, secondary cases may arise through exposure to MDR TB in the community. To estimate the frequency of multiple introductions of MDR TB into households, we used spoligotyping and 24-loci mycobacterial interspersed repetitive unit- variable number tandem repeats to classify isolates from 101 households in Lima, Peru, in which >1 MDR TB patient received treatment during 1996-2004. We found different MDR TB strains in >10% of households. Alternate approaches for classifying matching strains produced estimates of multiple introductions in <38% of households. At least 4% of MDR TB patients were reinfected by a second strain of MDR Mycobacterium tuberculosis. These findings suggest that community exposure to MDR TB in Lima occurs frequently. Rapid drug sensitivity testing of strains from household contacts of known MDR TB patients is needed to identify optimal treatment regimens.
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