ArticleMagnetic resonance in medicine2012
In vivo magnetic resonance imaging of sodium and diffusion in rat glioma at 21.1 T.
Article in Magnetic resonance in medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Advancing glioblastoma research by establishing a whole brain slice model.Frontiers in oncology · 2026Article
- The use of sodium MRI in the diagnosis of an anaplastic astrocytoma during immunotherapy: a case report.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- A safety study on ultra‑high or moderate static magnetic fields combined with platycodin D against lung cancer.Oncology letters · 2023Article
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- Sodium MRI at 7T for Early Response Evaluation of Intracranial Tumors following Stereotactic Radiotherapy Using the CyberKnife.AJNR. American journal of neuroradiology · 2022Article
- Noninvasive visualization of electrical conductivity in tissues at the micrometer scale.Science advances · 2021Article
- Sodium homeostasis in the tumour microenvironment.Biochimica et biophysica acta. Reviews on cancer · 2019Review
- Advances in Magnetic Noble Metal/Iron-Based Oxide Hybrid Nanoparticles as Biomedical Devices.Bioengineering (Basel, Switzerland) · 2019Review
- Use of MRI, metabolomic, and genomic biomarkers to identify mechanisms of chemoresistance in glioma.Cancer drug resistance (Alhambra, Calif.) · 2019Review
- Multipulse sodium magnetic resonance imaging for multicompartment quantification: Proof-of-concept.Scientific reports · 2017Article
- Open Source 3D Multipurpose Measurement System with Submillimetre Fidelity and First Application in Magnetic Resonance.Scientific reports · 2017Article
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- Article
- Sodium 3D COncentration MApping (COMA 3D) using (23)Na and proton MRI.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2014Article
- Sodium MRI: methods and applications.Progress in nuclear magnetic resonance spectroscopy · 2014Review
- A method for estimating intracellular sodium concentration and extracellular volume fraction in brain in vivo using sodium magnetic resonance imaging.Scientific reports · 2014Article
- In vivo chlorine and sodium MRI of rat brain at 21.1 T.Magma (New York, N.Y.) · 2014Article
- Biomedical applications of sodium MRI in vivo.Journal of magnetic resonance imaging : JMRI · 2013Review
- Sodium MRI and the assessment of irreversible tissue damage during hyper-acute stroke.Translational stroke research · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Sodium and diffusion magnetic resonance imaging (MRI) in intracranial rat 9L gliomas were evaluated over 6-8 days using the advanced sensitivity of sodium MRI at 21.1 T. Glioma doubling time was 2.4-2.6 days. Glioma sodium signal was detected using the ultra-short echo time of 0.15 ms. The high resolution 3D sodium MRI with pixels of 0.125 μL allowed for minimizing a partial volume effect often relevant to the MRI of low intensity signals. Tumor sodium and diffusion MRI were evaluated for two separate subclones of 9L cells with different resistance to 1,3-bis(2-chloroethyl)-1-nitrosurea detected by pre-surgery assays. In vivo, after implantation, resistant 9L cells created tumors with significantly reduced sodium concentrations (57 ± 3 mM) compared with nonresistant 9L cells (78 ± 3 mM). The corresponding differences in diffusion were less, but also statistically significant. During tumor progression, an increase of glioma sodium concentration was observed in both cell types with a rate of 2.4-5.8 %/day relative to normal brain. Tumor diffusion was not significantly changed at this time, indicative of no alterations in glioma cellularity. Thus, changes in sodium during tumor progression reflect increasing intracellular sodium concentration and mounting metabolic stress. These experiments also demonstrate an enhanced sensitivity of sodium MRI to reflect tumor cell resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.