Evidence map›Paper›PMID 21748445›Full record

Trial reportJournal of assisted reproduction and genetics2011

Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems.

Ozlem Gun Eryilmaz, Aysun Devran, Esma Sarikaya, Fatma Nur Aksakal, Leyla Mollamahmutoğlu, Nedim Cicek

2 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of assisted reproduction and genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 60 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 12 pooled it
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06139757 completednot on this mapstarted 2024, after this paper: background citation

Sleep Length and Euploid Embryo Transfer Prospective Study

TypeobservationalSponsorNorthwestern UniversityRan2024 to 2025Enrolled150ConditionsInfertility, FemaleArmsOura ring
NCT06546774 narecruitingnot on this mapstarted 2021, after this paper: background citation

The Effect of Melatonin Supplementation on Cumulus Cells and Reproductive Outcomes in Older Women Undergoing IVF Cycles

TypeinterventionalSponsorKaohsiung Veterans General Hospital.Ran2021 to 2025Enrolled200ConditionsUnrecognized ConditionArmsMelatonin
3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 12 syntheses or guidelines pooled it, 101 citations in OpenAlex.

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  10. Antioxidants for female subfertility.The Cochrane database of systematic reviews · 2020
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  12. Antioxidants for female subfertility.The Cochrane database of systematic reviews · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ozlem Gun EryilmazIVF Department, Zekai Tahir Burak Women Education and Research Hospital, Devlet Mah. Subay Loj. Hızırreis Apt. No: 19/11, Yenisehir, Ankara, Turkey. drozlemgun@yahoo.com
Aysun Devran
Esma Sarikaya
Fatma Nur Aksakal
Leyla Mollamahmutoğlu
Nedim Cicek
Zekai Tahir Burak Kadın Sağlığı Eğitim ve Araştırma Hastanesi · TRGazi University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe aimed to analyse the in vitro fertilization-embryo transfer (IVF-ET) outcomes of the patients with sleep disturbances who were administered melatonin.

methodsA total of 60 patients with sleep disturbances were divided into two groups. The study group (group A, n=30) had underwent the IVF-ET with melatonin administration and the control group (group B, n=30) without melatonin. Sleeping status after melatonin administration and the IVF outcomes were compared between the two groups.

resultsSleeping status change was not significant (p>0.05). The mean number of the retrieved oocytes, the mean MII oocyte counts, the G1 embryo ratio were significantly higher in the melatonin administered group (group A) than that the non-administered group (group B); p=0.0001; p=0.0001; p<0.05 respectively.

conclusionIVF patients with sleep disorders may benefit from melatonin administration in improving the oocyte and the embryo quality, but the sleeping problem itself may not be fixed.

Indexed as

Fertilization in VitroCentral Nervous System DepressantsEmbryo, MammalianEmbryo TransferFemaleHumansInfertility, FemaleMelatoninOocytesPregnancyPregnancy RateSleep Wake DisordersStress, PsychologicalCentral Nervous System DepressantsMelatonin

Identifiers

PMID21748445
PMCPMC3169684
OpenAlexW2029781335

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.