ArticleBiomechanics and modeling in mechanobiology2012
Human annulus fibrosus material properties from biaxial testing and constitutive modeling are altered with degeneration.
Article in Biomechanics and modeling in mechanobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06663592 (Effectiveness of Slider and Tensioner Neurodynamic Mobilization Techniques in Patients With Cervical Radiculopathy), which is not on this map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Slider and Tensioner Neurodynamic Mobilization Techniques in Patients With Cervical Radiculopathy: A Randomized Controlled Trial
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 117 citations in OpenAlex.
- Design Requirements for Annulus Fibrosus Repair: Review of Forces, Displacements, and Material Properties of the Intervertebral Disk and a Summary of Candidate Hydrogels for Repair.Journal of biomechanical engineering · 2016Pooled it
- Mechanical Characterization of Non-degraded Porcine Annulus Fibrosus Material Properties.Annals of biomedical engineering · 2026Article
- Finite element models of intervertebral disc: recent advances and prospects.Annals of medicine · 2025Review
- Microstructure and In-Plane Mechanical Property Comparison of Human and Porcine Cornea.Journal of biomechanical engineering · 2025Article
- A finite element study of the effect of cross-link stabilisation in a lumbar spine tumour model.Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine · 2025Article
- Human Disc Degeneration Is Accompanied by a Loss of Anterior Annulus Fibrosus Interlamellar Matrix Integrity as Assessed by Peel Tests.JOR spine · 2025Article
- Effect of walking with an active ankle exoskeleton on the biomechanical responses of the lumbar spine.Frontiers in bioengineering and biotechnology · 2025Article
- Influence of disc height and strain-dependent solute diffusivity on metabolic transport in patient-personalized intervertebral disc models.Frontiers in bioengineering and biotechnology · 2025Article
- An Approach to Quantify Anisotropic Multiaxial Failure of the Annulus Fibrosus.Journal of biomechanical engineering · 2024Article
- Comparative FEM study on intervertebral disc modeling: Holzapfel-Gasser-Ogden vs. structural rebars.Frontiers in bioengineering and biotechnology · 2024Article
- Polymeric Hydrogels for Intervertebral Disc Replacement/Integration: Playing with the Chemical Composition for Tuning Shear Behavior and Hydrophilicity.Gels (Basel, Switzerland) · 2023Article
- A Microstructure-Based Mechanistic Approach to Detect Degeneration Effects on Potential Damage Zones and Morphology of Young and Old Human Intervertebral Discs.Annals of biomedical engineering · 2023Article
- Textile Design of an Intervertebral Disc Replacement Device from Silk Yarn.Biomimetics (Basel, Switzerland) · 2023Article
- MRI-based measurement of in vivo disc mechanics in a young population due to flexion, extension, and diurnal loading.JOR spine · 2023Article
- Anatomically and Biomechanically Relevant Monolithic Total Disc Replacement Made of 3D-Printed Thermoplastic Polyurethane.Polymers · 2022Article
- Disc geometry measurement methods affect reported compressive mechanics by up to 65.JOR spine · 2022Article
- Computational Challenges in Tissue Engineering for the Spine.Bioengineering (Basel, Switzerland) · 2021Review
- Interlamellar matrix governs human annulus fibrosus multiaxial behavior.Scientific reports · 2020Article
- Multiscale composite model of fiber-reinforced tissues with direct representation of sub-tissue properties.Biomechanics and modeling in mechanobiology · 2020Article
- Mechanics of pulmonary airways: Linking structure to function through constitutive modeling, biochemistry, and histology.Acta biomaterialia · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The annulus fibrosus (AF) of the intervertebral disk undergoes large and multidirectional stresses and strains. Uniaxial tensile tests are limited for measuring AF material properties, because freely contracting edges can prevent fiber stretch and are not representative of in situ boundary conditions. The objectives of this study were to measure human AF biaxial tensile mechanics and to apply and validate a constitutive model to determine material properties. Biaxial tensile tests were performed on samples oriented along the circumferential-axial and the radial-axial directions. Data were fit to a structurally motivated anisotropic hyperelastic model composed of isotropic extra-fibrillar matrix, nonlinear fibers, and fiber-matrix interactions (FMI) normal to the fibers. The validated model was used to simulate shear and uniaxial tensile behavior, to investigate AF structure-function, and to quantify the effect of degeneration. The biaxial stress-strain response was described well by the model (R (2) > 0.9). The model showed that the parameters for fiber nonlinearity and the normal FMI correlated with degeneration, resulting in an elongated toe-region and lower stiffness with degeneration. The model simulations in shear and uniaxial tension successfully matched previously published circumferential direction Young's modulus, provided an explanation for the low values in previously published axial direction Young's modulus, and was able to simulate shear mechanics. The normal FMI were important contributors to stress and changed with degeneration, therefore, their microstructural and compositional source should be investigated. Finally, the biaxial mechanical data and constitutive model can be incorporated into a disk finite element model to provide improved quantification of disk mechanics.
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Registered trials
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