ArticleBehavior genetics2012
A note on false positives and power in G × E modelling of twin data.
Article in Behavior genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
99 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gene-environment interplay in depressive symptoms: moderation by age, sex, and physical illness.Psychological medicine · 2017Pooled it
- IGEMS: The Consortium on Interplay of Genes and Environment Across Multiple Studies - An Update.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2019Trial
- Article
- The nature and nurture of primary and secondary callous-unemotional traits: evidence from two independent twin samples.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Gene-Environment Interplay Between Residential Walkability and BMI: A Finnish Twin Study.Obesity (Silver Spring, Md.) · 2026Article
- Moderating the Heritability of Body Mass Index by Age and Sex With Genomic Data.Genetic epidemiology · 2026Article
- Within-Person Changes in Daily Ovarian Hormone Levels Influence Genetic Effects on Emotional Eating in Women.The International journal of eating disorders · 2025Article
- Genetic and environmental influences on alcohol consumption in middle to late life.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2025Article
- Associations of Romantic Partners' Characteristics with Alcohol Consumption and Binge Drinking: Examining Evidence for Gene-Environment Interaction.Clinical psychological science : a journal of the Association for Psychological Science · 2025Article
- Gene-environment interaction in ADHD traits: the role of school environment, personality, callousness-unemotional traits and satisfaction with life.European child & adolescent psychiatry · 2025Article
- Research Review: A review of the past decade of family and genomic studies on adolescent mental health.Journal of child psychology and psychiatry, and allied disciplines · 2025Review
- Gene-environment interplay in the relationship between the visibility of the environment and self-reported depression in early midlife: a Finnish twin cohort study.medRxiv : the preprint server for health sciences · 2025Article
- Genetic and environmental contributions to adult attachment styles: Evidence from the Minnesota Twin Registry.Journal of personality and social psychology · 2025Article
- Identifying gene-environment interactions across genome-wide, twin, and polygenic risk score approaches.Frontiers in genetics · 2025Article
- Testing the Deliberate Practice Theory: Does Practice Reduce the Heritability of Musical Expertise?Journal of Intelligence · 2024Article
- Gene-environment interaction between gaming addiction and perceived stress in late adolescents and young adults: A twin study.Journal of behavioral addictions · 2024Article
- Child effects on positive parenting vary with neighborhood opportunity.Developmental psychology · 2024Article
- Are Genetic and Environmental Risk Factors for Psychopathology Amplified in Children with Below-Average Intelligence? A Population-Based Twin Study.Behavior genetics · 2024Article
- Relationship between cognitive ability and emotional problems in the context of poverty: a Nigerian adolescent twin study.European child & adolescent psychiatry · 2024Article
- Socioeconomic status and risk for child psychopathology: exploring gene-environment interaction in the presence of gene-environment correlation using extended families in the Norwegian Mother, Father and Child Birth Cohort Study.Journal of child psychology and psychiatry, and allied disciplines · 2024Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The variance components models for gene-environment interaction proposed by Purcell in 2002 are widely used. In both the bivariate and the univariate parameterization of these models, the variance decomposition of trait T is a function of moderator M. We show that if M and T are correlated, and moderator M is correlated between twins as well, the univariate parameterization produces a considerable increase in false positive moderation effects. A simple extension of this univariate moderation model prevents this elevation of the false positive rate provided the covariance between M and T is itself not also subject to moderation. If the covariance between M and T varies as a function of M, then moderation effects observed in the univariate setting should be interpreted with care as these can have their origin in either moderation of the covariance between M and T or in moderation of the unique paths of T. We conclude that researchers should use the full bivariate moderation model to study the presence of moderation on the covariance between M and T. If such moderation can be ruled out, subsequent use of the extended univariate moderation model, as proposed in this paper, is recommended as this model is more powerful than the full bivariate moderation model.
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