ArticleMarine biotechnology (New York, N.Y.)2012
Role of hypoxia-inducible factor α in response to hypoxia and heat shock in the Pacific oyster Crassostrea gigas.
Article in Marine biotechnology (New York, N.Y.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- HIF-1α interacting with miR-2013-3p regulates pathogen-induced energy production changes via targeting glutamate dehydrogenase in the sea urchinVirulence · 2024Article
- Role of the Neuroendocrine System of Marine Bivalves in Their Response to Hypoxia.International journal of molecular sciences · 2023Review
- Effect of Air Exposure-Induced Hypoxia on Neurotransmitters and Neurotransmission Enzymes in Ganglia of the ScallopInternational journal of molecular sciences · 2022Article
- Hypoxia inducible factor-1Biology letters · 2020Article
- Combined and independent effects of hypoxia and tributyltin on mRNA expression and physiology of the Eastern oyster (Crassostrea virginica).Scientific reports · 2020Article
- Modulated Expression and Activities ofFrontiers in physiology · 2020Article
- Article
- Transcriptome Analysis of the Sydney Rock Oyster, Saccostrea glomerata: Insights into Molluscan Immunity.PloS one · 2016Article
- Hypoxia-Inducible Factor α and Hif-prolyl Hydroxylase Characterization and Gene Expression in Short-Time Air-Exposed Mytilus galloprovincialis.Marine biotechnology (New York, N.Y.) · 2015Article
- Proteomic responses to hypoxia at different temperatures in the great scallop (Pecten maximus).PeerJ · 2015Article
- Biomarkers of dissolved oxygen stress in oysters: a tool for restoration and management efforts.PloS one · 2014Article
- Regulation of a truncated isoform of AMP-activated protein kinase α (AMPKα) in response to hypoxia in the muscle of Pacific oyster Crassostrea gigas.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2013Article
- Article
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2 authors.
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Abstract
The Pacific oyster Crassostrea gigas inhabits the intertidal zone and shows tolerance to stress conditions such as hypoxia and heat shock. Although some information is available about the genes expressed in response to hypoxia, little is known about the molecular mechanism of the regulation of their expression in mollusks, including the Pacific oyster. Hypoxia-inducible factor 1α (HIF-1α) is a master regulator of hypoxia-responsive transcription. In this study, we cloned HIF-α from the oyster and investigated its response to unique stress conditions, including air exposure, for the first time in mollusks. The cDNA of oyster Hif-α is 3,182 bp long, of which 2,094 bp encodes a protein of 698 amino acid residues. Northern and Western blot analysis showed that expression of oyster HIF-α mRNA and protein were induced by air exposure, and that expression was induced periodically during air exposure. In addition, induction of Hif-α mRNA increased by a maximum 8.0-fold by heat shock. Under heat shock at 35°C (lethal temperature for the oyster), however, it was induced later than at 30°C. After recovery from hypoxia and/or heat shock, Hif-α mRNA also upregulated. These data suggest that the oyster has a strategy to induce Hif-α mRNA in order to survive hypoxia and heat shock, and that HIF signaling is necessary for recovery from stress.
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