ArticleCancer causes & control : CCC2011
Lifetime physical activity and the incidence of proliferative benign breast disease.
Article in Cancer causes & control : CCC, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Associations of oral contraceptives with expression of CD44, CD24, and ALDH1A1 stem cell markers in women with benign breast biopsies.Breast cancer research : BCR · 2026Article
- Reproductive factors and expression of stem cell markers in women with incident benign breast disease.American journal of cancer research · 2024Article
- Investigating the Link between Early Life and Breast Anomalies.Children (Basel, Switzerland) · 2023Review
- Physical activity and risk of benign proliferative epithelial disorders of the breast, in the Women's Health Initiative.International journal of epidemiology · 2022Article
- Risk factors for breast cancer development by tumor characteristics among women with benign breast disease.Breast cancer research : BCR · 2021Article
- Deep Learning Image Analysis of Benign Breast Disease to Identify Subsequent Risk of Breast Cancer.JNCI cancer spectrum · 2021Article
- Higher Dietary Inflammatory Index Scores are Associated with Increased Odds of Benign Breast Diseases in a Case-Control Study.Journal of inflammation research · 2020Article
- How does the social environment during life course embody in and influence the development of cancer?International journal of public health · 2018Review
- Monitoring modifiable risk factors for breast cancer: an obligation for health professionals.Revista panamericana de salud publica = Pan American journal of public health · 2017Article
- A prospective study of endometriosis and risk of benign breast disease.Breast cancer research and treatment · 2016Article
- Adolescent physical activity and inactivity: a prospective study of risk of benign breast disease in young women.Breast cancer research and treatment · 2014Article
- Recreational and household physical activity at different time points and DNA global methylation.European journal of cancer (Oxford, England : 1990) · 2013Article
- Preadolescent and adolescent risk factors for benign breast disease.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2013Review
- Physical activity and cancer.Current oncology reports · 2012Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundExercise is a modifiable factor that is inversely related to risk for breast cancer. To determine if physical activity has a preventative effect on development of premalignant breast lesions, we examined the association between exercise and the incidence of proliferative benign breast disease.
methodsIn 1997, the Nurses' Health Study II cohort reported levels of physical activity during adolescence and adulthood using a validated recall instrument. We followed 40,318 participants free from benign breast disease (BBD) or cancer prospectively for four years and confirmed 232 proliferative benign breast lesions by centralized pathology review. Cox proportional hazards models estimated the age-adjusted and multivariable-adjusted relative risks for physical activity and proliferative benign breast disease.
resultsWe observed a significant inverse association for walking and incidence of BBD, risk was reduced by 9% per hour of walking (95% CI 0% to 17%), (p trend = 0.05). Despite a small number of cases, risk of columnar cell lesions also suggested an inverse association with strenuous activity (RR for 4 or more hours of strenuous activity per week = 0.62; 0.31-1.22 compared to < 1 h per week).
conclusionsThis study suggests that exercise may be inversely associated with the risk of developing proliferative benign breast disease, one of the earliest steps in the development of breast cancer.
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