ArticlePsychopharmacology2012
Measuring the incentive value of escalating doses of heroin in heroin-dependent Fischer rats during acute spontaneous withdrawal.
Article in Psychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Sex differences in the expression of morphine withdrawal symptoms and associated activity in the tail of the ventral tegmental area.Neuroscience letters · 2019Article
- Effects of heroin on rat prosocial behavior.Addiction biology · 2019Article
- Expression of brain-derived neurotrophic factors, neurotrophin-3, and neurotrophin-4 in the nucleus accumbens during heroin dependency and withdrawal.Neuroreport · 2017Article
- Adolescent oxycodone self administration alters subsequent oxycodone-induced conditioned place preference and anti-nociceptive effect in C57BL/6J mice in adulthood.Neuropharmacology · 2016Article
- Cerebellar neuronal apoptosis in heroin-addicted rats and its molecular mechanism.International journal of clinical and experimental pathology · 2015Article
- Self administration of oxycodone by adolescent and adult mice affects striatal neurotransmitter receptor gene expression.Neuroscience · 2014Article
- Suppression of hypothalamic-pituitary-adrenal axis by acute heroin challenge in rats during acute and chronic withdrawal from chronic heroin administration.Neurochemical research · 2013Article
- Article
- Tolerance and sensitization to chronic escalating dose heroin following extended withdrawal in Fischer rats: possible role of mu-opioid receptors.Psychopharmacology · 2013Article
- The effects of acute and chronic steady state methadone on memory retrieval in rats.Psychopharmacology · 2012Article
- Dose escalation and dose preference in extended-access heroin self-administration in Lewis and Fischer rats.Psychopharmacology · 2012Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
RATIONALE/
objectivesAlthough continued heroin use and relapse are thought to be motivated, in part, by the positive incentive-motivational value attributed to heroin, little is understood about heroin's incentive value during the relapse-prone state of withdrawal. This study uses place preference to measure the incentive value attributed to escalating-dose heroin in the context of heroin dependence.
methodsMale Fischer rats were exposed chronically to escalating doses of heroin in the homecage and during place preference conditioning sessions. Conditioned preference for the context paired with escalating-dose heroin was tested after homecage exposure was discontinued and rats entered acute spontaneous withdrawal. Individuals' behavioral and locomotor responses to heroin and somatic withdrawal signs were recorded.
resultsConditioned preference for the heroin-paired context was strong in rats that received chronic homecage exposure to escalating-dose heroin and were tested in acute withdrawal. Behavioral responses to heroin (e.g., stereotypy) varied widely across individuals, with rats that expressed stronger heroin preference also expressing stronger behavioral activation in response to heroin. Individual differences in preference were also related to locomotor responses to heroin but not to overt somatic withdrawal signs.
conclusionsEscalating doses of heroin evoked place preference in rats, suggesting that positive incentive-motivational value is attributed to this clinically relevant pattern of drug exposure. This study offers an improved preclinical model for studying dependence and withdrawal and provides insight into individual vulnerabilities to addiction-like behavior.
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