ArticleJournal of fluorescence2011
Aurones: small molecule visible range fluorescent probes suitable for biomacromolecules.
Article in Journal of fluorescence, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 73 citations in OpenAlex.
- Photochemical access to flavone- and aurone-fused estrone derivatives.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025Article
- Solvent-Dependent Emissions Properties of a Model Aurone Enable Use in Biological Applications.Journal of fluorescence · 2025Article
- A novel aurone RNA CAG binder inhibits the huntingtin RNA-protein interaction.RSC medicinal chemistry · 2024Article
- Prenylated Flavonoids with Selective Toxicity against Human Cancers.International journal of molecular sciences · 2023Article
- Facile Detection of Light-Controlled Radical Scavengers from Natural Products Using In Situ UV-LED NMR Spectroscopy.Antioxidants (Basel, Switzerland) · 2022Article
- Aurone-derived 1,2,3-triazoles as potential fluorescence moleculesRSC advances · 2022Article
- Aurones: A Golden Resource for Active Compounds.Molecules (Basel, Switzerland) · 2021Review
- Molecular photoswitches in aqueous environments.Chemical Society reviews · 2021Review
- Photophysical Study and Biological Applications of Synthetic Chalcone-Based Fluorescent Dyes.Molecules (Basel, Switzerland) · 2021Article
- Hydrogen sulfide sensing using an aurone-based fluorescent probe.RSC advances · 2020Article
- A golden opportunity: benzofuranone modifications of aurones and their influence on optical properties, toxicity, and potential as dyes.Beilstein journal of organic chemistry · 2019Article
- The Influence of Glycosylation of Natural and Synthetic Prenylated Flavonoids on Binding to Human Serum Albumin and Inhibition of Cyclooxygenases COX-1 and COX-2.Molecules (Basel, Switzerland) · 2017Article
- Study of Fluorescent Imaging of Se (IV) in Living Cells Using a Turn-on Fluorescent Probe Based on a Rhodamine Spirolactame Derivative.Journal of fluorescence · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Aurones, derivatives of 2-benylidenebenzofuran-3(2H)-one, are natural products that serve as plant pigments. There have been reports that some of these substances fluoresce, but little information about their optical properties is in the literature. In this report, series of aurone derivatives were synthesized as possible fluorescent probes that can be excited by visible light. We found that an amine substituent shifted the lowest energy absorption band from the near-UV to the visible region of the electromagnetic spectrum. Four amine-substituted aurone derivatives were synthesized to explore the effect of this substituent on the absorption and emission properties of the aurone chromophore. The emission maxima and intensities of the molecules are strongly dependent on the nature of the substituent and the solvent polarity. Overall, the emission intensity increases and the maximum wavelength decreases in less polar solvents; thus, the aurones may be useful probes for hydrophobic sites on biological molecules. A limited investigation with model protein, nucleic acid and fixed cells supports this idea. It is known that the sulfur analog of aurone can undergo photo-induced E/Z isomerization. This possibility was investigated for one of the aminoaurones, which was observed to reversible photoisomerize. The two isomers have similar absorption spectra, but the emission properties are distinct. We conclude that appropriately substituted aurones are potentially useful as biological probes and photoswitches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.