ArticlePloS one2011
The Drosophila gap gene network is composed of two parallel toggle switches.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- Global maps of transcription factor properties reveal threshold-based formation of DNA-bound and mobile clusters.Science advances · 2026Article
- Bulk-level maps of pioneer factor binding dynamics during the Drosophila maternal-to-zygotic transition.Development (Cambridge, England) · 2025Article
- A bistable autoregulatory module in the developing embryo commits cells to binary expression fates.Current biology : CB · 2023Article
- Latent space of a small genetic network: Geometry of dynamics and information.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Monostability and bistability of biological switches.Journal of mathematical biology · 2021Article
- An Esrrb and Nanog Cell Fate Regulatory Module Controlled by Feed Forward Loop Interactions.Frontiers in cell and developmental biology · 2021Article
- Bayesian model selection for the Drosophila gap gene network.BMC bioinformatics · 2019Article
- The engineering principles of combining a transcriptional incoherent feedforward loop with negative feedback.Journal of biological engineering · 2019Article
- A Tug-of-War Mechanism for Pattern Formation in a Genetic Network.ACS synthetic biology · 2017Article
- Translating natural genetic variation to gene expression in a computational model of the Drosophila gap gene regulatory network.PloS one · 2017Article
- Predicting Ancestral Segmentation Phenotypes from Drosophila to Anopheles Using In Silico Evolution.PLoS genetics · 2016Article
- Temporal and spatial dynamics of scaling-specific features of a gene regulatory network in Drosophila.Nature communications · 2015Article
- Single-Cell Analyses of ESCs Reveal Alternative Pluripotent Cell States and Molecular Mechanisms that Control Self-Renewal.Stem cell reports · 2015Article
- NetExplore: a web server for modeling small network motifs.Bioinformatics (Oxford, England) · 2015Article
- A gene expression atlas of a bicoid-depleted Drosophila embryo reveals early canalization of cell fate.Development (Cambridge, England) · 2015Article
- Mid-embryo patterning and precision in Drosophila segmentation: Krüppel dual regulation of hunchback.PloS one · 2015Article
- In silico evolution of the hunchback gene indicates redundancy in cis-regulatory organization and spatial gene expression.Journal of bioinformatics and computational biology · 2014Article
- Review
- Article
- Dynamic interpretation of maternal inputs by the Drosophila segmentation gene network.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Drosophila "gap" genes provide the first response to maternal gradients in the early fly embryo. Gap genes are expressed in a series of broad bands across the embryo during first hours of development. The gene network controlling the gap gene expression patterns includes inputs from maternal gradients and mutual repression between the gap genes themselves. In this study we propose a modular design for the gap gene network, involving two relatively independent network domains. The core of each network domain includes a toggle switch corresponding to a pair of mutually repressive gap genes, operated in space by maternal inputs. The toggle switches present in the gap network are evocative of the phage lambda switch, but they are operated positionally (in space) by the maternal gradients, so the synthesis rates for the competing components change along the embryo anterior-posterior axis. Dynamic model, constructed based on the proposed principle, with elements of fractional site occupancy, required 5-7 parameters to fit quantitative spatial expression data for gap gradients. The identified model solutions (parameter combinations) reproduced major dynamic features of the gap gradient system and explained gap expression in a variety of segmentation mutants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.