ArticlePloS one2011
Serological evidence of discrete spatial clusters of Plasmodium falciparum parasites.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Reactive, self-administered malaria treatment against asymptomatic malaria infection: results of a cluster randomized controlled trial in The Gambia.Malaria journal · 2021Trial
- Trial
- Trial
- Antibodies to PfEMP1 and variant surface antigens: Protection after controlled human malaria infection in semi-immune Kenyan adults.The Journal of infection · 2024Article
- Maintenance of high temporal Plasmodium falciparum genetic diversity and complexity of infection in asymptomatic and symptomatic infections in Kilifi, Kenya from 2007 to 2018.Malaria journal · 2022Article
- Investigating the drivers of the spatio-temporal patterns of genetic differences between Plasmodium falciparum malaria infections in Kilifi County, Kenya.Scientific reports · 2019Article
- Analysis of serological data to investigate heterogeneity of malaria transmission: a community-based cross-sectional study in an area conducting elimination in Indonesia.Malaria journal · 2019Article
- Interaction between maternally derived antibodies and heterogeneity in exposure combined to determine time-to-first Plasmodium falciparum infection in Kenyan infants.Malaria journal · 2019Article
- Micro-epidemiology of malaria in an elimination setting in Central Vietnam.Malaria journal · 2018Article
- Controlled Human Malaria Infection in Semi-Immune Kenyan Adults (CHMI-SIKA): a study protocol to investigateWellcome open research · 2018Article
- Identification of immune signatures predictive of clinical protection from malaria.PLoS computational biology · 2017Article
- Impact of metric and sample size on determining malaria hotspot boundaries.Scientific reports · 2017Article
- Micro-epidemiological structuring ofWellcome open research · 2017Article
- Spatio-temporal heterogeneity of malaria vectors in northern Zambia: implications for vector control.Parasites & vectors · 2016Article
- Development of new malaria diagnostics: matching performance and need.Malaria journal · 2016Article
- Antibody acquisition models: A new tool for serological surveillance of malaria transmission intensity.Scientific reports · 2016Article
- Use of different transmission metrics to describe malaria epidemiology in the highlands of western Kenya.Malaria journal · 2015Article
- Plasmodium vivax malaria at households: spatial clustering and risk factors in a low endemicity urban area of the northwestern Peruvian coast.Malaria journal · 2015Article
- Hotspots of Malaria Transmission in the Peruvian Amazon: Rapid Assessment through a Parasitological and Serological Survey.PloS one · 2015Article
- Hot spot or not: a comparison of spatial statistical methods to predict prospective malaria infections.Malaria journal · 2014Article
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMalaria transmission may be considered to be homogenous with well-mixed parasite populations (as in the classic Ross/Macdonald models). Marked fine-scale heterogeneity of transmission has been observed in the field (i.e., over a few kilometres), but there are relatively few data on the degree of mixing. Since the Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) is highly polymorphic, the host's serological responses may be used to infer exposure to parasite sub-populations. METHODS AND
findingsWe measured the antibody responses to 46 individual PfEMP1 domains at four time points among 450 children in Kenya, and identified distinct spatial clusters of antibody responses to individual domains. 35 domains showed strongly significant sero-clusters at p = 0.001. Individuals within the high transmission hotspot showed the greatest diversity of anti-PfEMP1 responses. Individuals outside the hotspot had a less diverse range of responses, even if as individuals they were at relatively intense exposure.
conclusionsWe infer that antigenically distinct sub-populations of parasites exist on a fine spatial scale in a study area of rural Kenya. Further studies should examine antigenic variation over longer periods of time and in different study areas.
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