ArticleFrontiers in systems neuroscience2011
Nitric Oxide-Soluble Guanylyl Cyclase-Cyclic GMP Signaling in the Striatum: New Targets for the Treatment of Parkinson's Disease?
Article in Frontiers in systems neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 65 citations in OpenAlex.
- The Emerging Role of Phosphodiesterase Inhibitors in Fragile X Syndrome and Autism Spectrum Disorder.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Article
- Targeting Striatal Glutamate and Phosphodiesterases to Control L-DOPA-Induced Dyskinesia.Cells · 2023Review
- 7-Nitroindazole reduces L-DOPA-induced dyskinesias in non-human Parkinsonian primate.Open biology · 2023Article
- Phosphodiesterase 9 inhibition prolongs the antiparkinsonian action of l-DOPA in parkinsonian non-human primates.Neuropharmacology · 2022Article
- Impairment of Nrf2- and Nitrergic-Mediated Gastrointestinal Motility in an MPTP Mouse Model of Parkinson's Disease.Digestive diseases and sciences · 2019Article
- Heat shock protein 90 regulates soluble guanylyl cyclase maturation by a dual mechanism.The Journal of biological chemistry · 2019Article
- Phosphodiesterase 9A in Brain Regulates cGMP Signaling Independent of Nitric-Oxide.Frontiers in neuroscience · 2019Article
- Activation of Protein Kinase G After Repeated Cocaine Administration Is Necessary for the Phosphorylation of α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptor GluA1 at Serine 831 in the Rat Nucleus Accumbens.Frontiers in molecular neuroscience · 2018Article
- Frequency-Dependent Corticostriatal Disinhibition Resulting from Chronic Dopamine Depletion: Role of Local Striatal cGMP and GABA-AR Signaling.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Cross-regulation of Phosphodiesterase 1 and Phosphodiesterase 2 Activities Controls Dopamine-mediated Striatal α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Trafficking.The Journal of biological chemistry · 2016Article
- Phosphodiesterase Inhibition and Regulation of Dopaminergic Frontal and Striatal Functioning: Clinical Implications.The international journal of neuropsychopharmacology · 2016Article
- Mutual Control of Cholinergic and Low-Threshold Spike Interneurons in the Striatum.Frontiers in cellular neuroscience · 2016Article
- Facilitation of corticostriatal transmission following pharmacological inhibition of striatal phosphodiesterase 10A: role of nitric oxide-soluble guanylyl cyclase-cGMP signaling pathways.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Age-related alterations in the expression of genes and synaptic plasticity associated with nitric oxide signaling in the mouse dorsal striatum.Neural plasticity · 2015Article
- Direct and indirect pathways of basal ganglia: a critical reappraisal.Nature neuroscience · 2014Review
- The role of glutamate and its receptors in multiple sclerosis.Journal of neural transmission (Vienna, Austria : 1996) · 2014Review
- Review: Modulation of striatal neuron activity by cyclic nucleotide signaling and phosphodiesterase inhibition.Basal ganglia · 2013Article
- Dopamine in the pathogenesis of minimal hepatic encephalopathy: a new player?Hepatology international · 2013Article
- Ischemic-LTP in striatal spiny neurons of both direct and indirect pathway requires the activation of D1-like receptors and NO/soluble guanylate cyclase/cGMP transmission.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Striatal nitric oxide (NO)-producing interneurons play an important role in the regulation of corticostriatal synaptic transmission and motor behavior. Striatal NO synthesis is driven by concurrent activation of NMDA and dopamine (DA) D1 receptors. NO diffuses into the dendrites of medium-sized spiny neurons which contain high levels of NO receptors called soluble guanylyl cyclases (sGC). NO-mediated activation of sGC leads to the synthesis of the second messenger cGMP. In the intact striatum, transient elevations in intracellular cGMP primarily act to increase neuronal excitability and to facilitate glutamatergic corticostriatal transmission. NO-cGMP signaling also functionally opposes the inhibitory effects of DA D2 receptor activation on corticostriatal transmission. Not surprisingly, abnormal striatal NO-sGC-cGMP signaling becomes apparent following striatal DA depletion, an alteration thought to contribute to pathophysiological changes observed in basal ganglia circuits in Parkinson's disease (PD). Here, we discuss recent developments in the field which have shed light on the role of NO-sGC-cGMP signaling pathways in basal ganglia dysfunction and motor symptoms associated with PD and l-DOPA-induced dyskinesias.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.