ArticleDiagnostic and therapeutic endoscopy2011
Carbon dioxide insufflation in routine colonoscopy is safe and more comfortable: results of a randomized controlled double-blinded trial.
Article in Diagnostic and therapeutic endoscopy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01633333 (Water Exchange Versus Carbon Dioxide Insufflation to Improve Colonoscopy Screening - a Randomized Controlled Trial), which is not on this map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Water Exchange Versus Carbon Dioxide Insufflation to Improve Colonoscopy Screening - a Randomized Controlled Trial
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Carbon Dioxide vs. Air Insufflation for Pediatric Gastrointestinal Endoscopy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Frontiers in pediatrics · 2021Pooled it
- A meta-analysis of carbon dioxide versus room air insufflation on patient comfort and key performance indicators at colonoscopy.International journal of colorectal disease · 2020Pooled it
- Guideline
- Impact of responsive insertion technology (RIT) on reducing discomfort during colonoscopy: randomized clinical trial.Surgical endoscopy · 2017Trial
- Sigmoid pneumatosis cystoides intestinalis secondary to chronic digestive hyperpressure on post-ulcer duodenal bulb stenosis, decompensated following recent endoscopic insufflation.Journal of surgical case reports · 2026Article
- Occurrence of portal venous gas following routine endoscopy: a case report.Open medicine (Warsaw, Poland) · 2026Article
- In Situ Photoactivated Hydrogel Adhesive Dressings for Post Colon Polypectomies (PolypCures).bioRxiv : the preprint server for biology · 2025Article
- Comparative Effectiveness of Pharmacological, Non-Pharmacological, and Combined Strategies for Pain Relief During Colonoscopy: A Bayesian Network Meta-Analysis of Randomized Trials.Journal of pain research · 2025Review
- Carbon dioxide versus room air for colonoscopy in deeply sedated pediatric patients: a randomized controlled trial.Endoscopy international open · 2019Article
- Explosive Vomiting Associated with Proximal Colonic Distention during a Difficult Propofol-Assisted Colonoscopy.Case reports in anesthesiology · 2019Article
- Carbon dioxide insufflation during endoscopic resection of large colorectal polyps can reduce post-procedure abdominal pain: A prospective, double-blind, randomized controlled trial.United European gastroenterology journal · 2018Article
- Carbon dioxide versus air insufflation enteroscopy: a systematic review and meta-analysis based on randomized controlled trials.Endoscopy international open · 2018Article
- New Strategies to Improve Polypectomy During Colonoscopy.Gastroenterology & hepatology · 2017Article
- Carbon dioxide insufflation is associated with increased serrated polyp detection rate when compared to room air insufflation during screening colonoscopy.Endoscopy international open · 2017Article
- Is the type of insufflation a key issue in gastro-intestinal endoscopy?World journal of gastroenterology · 2014Review
- What Influences the Quality of Prevention Colonoscopy?Viszeralmedizin · 2014Review
- Bringing top-end endoscopy to regional australia: hurdles and benefits.Diagnostic and therapeutic endoscopy · 2012Article
- Carbon dioxide insufflation in colonoscopy is safe: a prospective trial of 347 patients.Diagnostic and therapeutic endoscopy · 2012Article
- Safety of chronic obstructive pulmonary disease patients undergoing carbon dioxide insufflation in extended endoscopic procedures.Lung India : official organ of Indian Chest SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many patients experience pain and discomfort after colonoscopy. Carbon dioxide (CO(2)) can reduce periprocedural pain although air insufflation remained the standard procedure. The objective of this double-blinded, randomized controlled trial was to evaluate whether CO(2) insufflation does decrease pain and bloating during and after colonoscopy compared to room air. Methods. 219 consecutive patients undergoing colonoscopy were randomized to either CO(2) or air insufflation. Propofol was used in all patients for sedation. Transcutaneous CO(2) was continuously measured with a capnograph as a safety parameter. Pain, bloating, and overall satisfaction were assessed at regular intervals before and after the procedure. Results(data are mean ±SD). 110 patients were randomized to CO(2) and 109 to room air. The baseline characteristics were similar in both groups. The mean propofol dose was not different between the treatments, as were the time to reach the ileum and the withdrawal time. pCO(2) at the end of the procedure was 35.2 ± 4.3 mmHg (CO(2) group) versus 35.6 ± 6.0 mmHg in the room air group (P > .05). No relevant complication occurred in either group. There was significantly less bloating for the CO(2) group during the postprocedural recovery period (P < .001) and over the 24-hour period (P < .001). Also, patients with CO(2) insufflation experienced significantly less pain (P = .014). Finally, a higher overall satisfaction (P = .04 ) was found in the CO(2) group. Conclusions. This trial provides compelling evidence that CO(2) insufflation significantly reduces bloating and pain after routine colonoscopy in propofol-sedated patients. The procedure is safe with no significant differences in CO(2) between the two groups.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.