ArticleMolecular psychiatry2012
Association between genetic variation in a region on chromosome 11 and schizophrenia in large samples from Europe.
Article in Molecular psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
59 citing papers in PubMed, 5 syntheses or guidelines pooled it, 116 citations in OpenAlex.
- Linking Polygenic Risk of Schizophrenia to Variation in Magnetic Resonance Imaging Brain Measures: A Comprehensive Systematic Review.Schizophrenia bulletin · 2024Pooled it
- Evaluation of European Schizophrenia GWAS Loci in Asian Populations via Comprehensive Meta-Analyses.Molecular neurobiology · 2017Pooled it
- Common variants in the MKL1 gene confer risk of schizophrenia.Schizophrenia bulletin · 2015Pooled it
- Systematic prioritization and integrative analysis of copy number variations in schizophrenia reveal key schizophrenia susceptibility genes.Schizophrenia bulletin · 2014Pooled it
- Pooled it
- Autophagy and Neuropsychiatric Disorders: Unraveling Molecular Mechanisms and Signaling Pathways.CNS & neurological disorders drug targets · 2026Review
- Cognitive Stress Regulation in Schizophrenia Patients and Healthy Individuals: Brain and Behavior.Journal of clinical medicine · 2023Article
- Polymorphism in the ZNF804A Gene and Variation in DBiological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Autophagopathies: from autophagy gene polymorphisms to precision medicine for human diseases.Autophagy · 2022Article
- Keeping the balance: Trade-offs between human brain evolution, autism, and schizophrenia.Frontiers in genetics · 2022Review
- Consensus on potential biomarkers developed for use in clinical tests for schizophrenia.General psychiatry · 2022Article
- Genome wide association study identifies four loci for early onset schizophrenia.Translational psychiatry · 2021Article
- Neurogranin, Encoded by the Schizophrenia Risk Gene NRGN, Bidirectionally Modulates Synaptic Plasticity via Calmodulin-Dependent Regulation of the Neuronal Phosphoproteome.Biological psychiatry · 2021Article
- Pathogenic Single Nucleotide Polymorphisms on Autophagy-Related Genes.International journal of molecular sciences · 2020Review
- Normalizing the Abnormal: Do Antipsychotic Drugs Push the Cortex Into an Unsustainable Metabolic Envelope?Schizophrenia bulletin · 2020Review
- Association of Cholinergic Muscarinic M4 Receptor Gene Polymorphism with Schizophrenia.The application of clinical genetics · 2020Article
- Neurodevelopmental Disorders: Functional Role of Ambra1 in Autism and Schizophrenia.Molecular neurobiology · 2019Review
- Expression analysis and genotyping of DGKZ: a GWAS-derived risk gene for schizophrenia.Molecular biology reports · 2019Article
- Article
- Functional genomics reveal gene regulatory mechanisms underlying schizophrenia risk.Nature communications · 2019Article
Corrections and comments
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Authors and funding
54 authors at 12 institutions in 5 countries.
Funding
Abstract
Recent molecular studies have implicated common alleles of small to moderate effect and rare alleles with larger effect sizes in the genetic architecture of schizophrenia (SCZ). It is expected that the reliable detection of risk variants with very small effect sizes can only be achieved through the recruitment of very large samples of patients and controls (that is tens of thousands), or large, potentially more homogeneous samples that have been recruited from confined geographical areas using identical diagnostic criteria. Applying the latter strategy, we performed a genome-wide association study (GWAS) of 1169 clinically well characterized and ethnically homogeneous SCZ patients from a confined area of Western Europe (464 from Germany, 705 from The Netherlands) and 3714 ethnically matched controls (1272 and 2442, respectively). In a subsequent follow-up study of our top GWAS results, we included an additional 2569 SCZ patients and 4088 controls (from Germany, The Netherlands and Denmark). Genetic variation in a region on chromosome 11 that contains the candidate genes AMBRA1, DGKZ, CHRM4 and MDK was significantly associated with SCZ in the combined sample (n=11 540; P=3.89 × 10(-9), odds ratio (OR)=1.25). This finding was replicated in 23 206 independent samples of European ancestry (P=0.0029, OR=1.11). In a subsequent imaging genetics study, healthy carriers of the risk allele exhibited altered activation in the cingulate cortex during a cognitive control task. The area of interest is a critical interface between emotion regulation and cognition that is structurally and functionally abnormal in SCZ and bipolar disorder.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.