Evidence map›Paper›PMID 21747392›Full record

ReviewNature reviews. Microbiology2011

Influenza A viruses: new research developments.

Rafael A Medina, Adolfo García-Sastre

Open access · bronzeAbstract readReview
In one paragraph

Review in Nature reviews. Microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 354 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
354citing papers in PubMed, 3 pooled it
36.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

354 citing papers in PubMed, 3 syntheses or guidelines pooled it, 671 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. A Phase 1/2 Dose-Ranging Safety and Immunogenicity Study of mRNA-Based Candidate Pandemic Influenza Vaccines in Healthy Adults.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Trial
  5. Article
  6. Virus-Mediated Self-Assembly of Functional Cyclodextrins for Antiviral Inhibition.Angewandte Chemie (International ed. in English) · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Sparse Evidence of Influenza C on US Dairy and Beef Cattle Farms.Influenza and other respiratory viruses · 2025
    Article
  17. Review
  18. Article
  19. Article
  20. Review

294 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Rafael A MedinaDepartment of Microbiology, and Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine.
Adolfo García-Sastre
Icahn School of Medicine at Mount Sinai · USMount Sinai Hospital · US

Funding

Viral Pathogenesis and TherapeuticsU54AI057158 · NIAID · WADSWORTH CENTER · PI LIPKIN, W. IAN · 2003 to 2014
$100.8M
Viral and Host cDNA Libraries from 1918 Influenza CasesP01AI058113 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI GARCIA-SASTRE, ADOLFO · 2004 to 2010
$20.3M
TRIM mediated host antiviral responses during influenza virus infectionsU19AI083025 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JUNG, JAE U · 2009 to 2013
$10.0M
Live attenuated vaccines for epidemic and pandemic fluU01AI070469 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GARCIA-SASTRE, ADOLFO · 2006 to 2010
$9.7M
VIRULENCE FACTORS OF INFLUENZA VIRUS--THE NS1 PROTEINR01AI046954 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI GARCIA-SASTRE, ADOLFO · 2000 to 2010
$3.1M
NIAID NIH HHS HHSN266200700010CNIAID NIH HHS P01 AI058113NIAID NIH HHS R01 AI046954NIAID NIH HHS U01 AI070469NIAID NIH HHS U19 AI083025NIAID NIH HHS U54 AI057158
6 · The paper itself

Abstract

Influenza A viruses are zoonotic pathogens that continuously circulate and change in several animal hosts, including birds, pigs, horses and humans. The emergence of novel virus strains that are capable of causing human epidemics or pandemics is a serious possibility. Here, we discuss the value of surveillance and characterization of naturally occurring influenza viruses, and review the impact that new developments in the laboratory have had on our understanding of the host tropism and virulence of viruses. We also revise the lessons that have been learnt from the pandemic viruses of the past 100 years.

Indexed as

Viral TropismAnimalsEvolution, MolecularHumansInfluenza A virusInfluenza, HumanModels, BiologicalOrthomyxoviridae InfectionsPandemicsVirulenceZoonoses

Identifiers

PMID21747392
PMCPMC10433403
OpenAlexW1995510727

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.