Evidence map›Paper›PMID 21747052›Full record

Trial reportCirculation2011

Insulin receptor substrate 1 gene variation modifies insulin resistance response to weight-loss diets in a 2-year randomized trial: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial.

Qibin Qi, George A Bray, Steven R Smith, Frank B Hu, Frank M Sacks, Lu Qi

3 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Circulation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 74 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 6 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00072995 nacompletednot on this map

Preventing Overweight Using Novel Dietary Strategies (Pounds Lost)

TypeinterventionalSponsorBrigham and Women's HospitalRan2003 to 2007Enrolled811ConditionsCardiovascular Diseases, Heart Diseases, ObesityArmsFour Diets Differing in Macronutrient Composition, Diets Low in Saturated Fat
NCT02519309 nacompletednot on this mapstarted 2015, after this paper: background citation

Dietary Intervention in Type-2 Diabetics and Pre-Diabetics Emphasizing Personalized Carbohydrate Intake

TypeinterventionalSponsorVirta HealthRan2015 to 2021Enrolled465ConditionsDiabetes Mellitus, Type 2, Pre-diabetes, Metabolic SyndromeArmsVirta Program
NCT05427799 nacompletednot on this mapstarted 2022, after this paper: background citation

The Influence of Daily Honey Consumption on Insulin Resistance in Obese Women With Insulin Resistance

TypeinterventionalSponsorUniversity of JordanRan2022 to 2024Enrolled20ConditionsInsulin ResistanceArmsHoney, Other carbohydrate alternatives such as jell-o
3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 6 syntheses or guidelines pooled it, 134 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Reduction in saturated fat intake for cardiovascular disease.The Cochrane database of systematic reviews · 2020
    Pooled it
  5. Reduction in saturated fat intake for cardiovascular disease.The Cochrane database of systematic reviews · 2020
    Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Dietary Protein Modifies the Effect of theThe Journal of nutrition · 2017
    Trial
  18. Trial
  19. Trial
  20. Trial

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Qibin QiDepartment of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.
George A Bray
Steven R Smith
Frank B Hu
Frank M Sacks
Lu Qi
Louisiana State University System · USPennington Biomedical Research Center · US

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
Zoledronic Acid in Treatment of Osteoporosis in PostmenoM01RR002635 · NCRR · BRIGHAM AND WOMEN'S HOSPITAL · PI GARBER, JUDY E. · 1985 to 2008
$48.4M
Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI GREENBERG, ANDREW S, PERISSI, VALENTINA · 1992 to 2021
$25.0M
Genetic Markers of CHD in Type 2 DiabetesR01HL071981 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI QI, LU · 2003 to 2012
$4.9M
Ontogeny of the intestinal mucosal barrier and NECR01DK070260 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI WALKER, W ALLAN · 2005 to 2009
$1.8M
NCRR NIH HHS M01 RR002635NCRR NIH HHS RR-02635NCRR NIH HHS UL1 RR025758NHLBI NIH HHS HL071981NHLBI NIH HHS R01 HL071981NIDDK NIH HHS DK46200NIDDK NIH HHS P30 DK046200NIDDK NIH HHS R01 DK070260
6 · The paper itself

Abstract

backgroundCommon genetic variants in the insulin receptor substrate 1 (IRS1) gene have been recently associated with insulin resistance and hyperinsulinemia. We examined whether the best-associated variant modifies the long-term changes in insulin resistance and body weight in response to weight-loss diets in Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial. METHODS AND

resultsWe genotyped IRS1 rs2943641 in 738 overweight adults (61% were women) who were randomly assigned to 1 of 4 diets varying in macronutrient contents for 2 years. We assessed the progress in fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR) and weight loss by genotypes. At 6 months, participants with the risk-conferring CC genotype had greater decreases in insulin (P=0.009), HOMA-IR (P=0.015), and weight loss (P=0.018) than those without this genotype in the highest-carbohydrate diet group whereas an opposite genotype effect on changes in insulin and HOMA-IR (P≤0.05) was observed in participants assigned to the lowest-carbohydrate diet group. No significant differences were observed across genotypes in the other 2 diet groups. The tests for genotype by intervention interactions were all significant (P<0.05). At 2 years, the genotype effect on changes in insulin and HOMA-IR remained significant in the highest-carbohydrate diet group (P<0.05). The highest carbohydrate diet led to a greater improvement of insulin and HOMA-IR (P for genotype-time interaction ≤0.009) in participants with the CC genotype than those without this genotype across 2-year intervention.

conclusionsIndividuals with the IRS1 rs2943641 CC genotype might obtain more benefits in weight loss and improvement of insulin resistance than those without this genotype by choosing a high-carbohydrate and low-fat diet. CLINICAL

trial registrationhttp:www.clinicaltrials.gov. Unique identifier: NCT00072995.

Indexed as

AdultDietary CarbohydratesDietary FatsDietary ProteinsDiet, ReducingEnergy IntakeFemaleGenetic VariationGenotypeHumansInsulinInsulin Receptor Substrate ProteinsInsulin ResistanceMaleMiddle AgedOverweightDietary CarbohydratesDietary FatsDietary ProteinsInsulinInsulin Receptor Substrate ProteinsIRS1 protein, human

Identifiers

PMID21747052
PMCPMC3171189
OpenAlexW2103207798

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.