ArticleArchives of ophthalmology (Chicago, Ill. : 1960)2011
Racial differences in ocular oxidative metabolism: implications for ocular disease.
Article in Archives of ophthalmology (Chicago, Ill. : 1960), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Tissue-Specific Antioxidant Capacity in Primary Open-Angle Glaucoma Patients.Investigative ophthalmology & visual science · 2026Article
- Oxygen uptake at the ocular surface in diabetic animals is impaired in response to central corneal injury.Experimental eye research · 2025Article
- Exploring ethnic and racial differences in intraocular pressure and glaucoma: The Canadian Longitudinal Study on aging.Heliyon · 2024Article
- Diabetic Ocular Surface Has Defects in Oxygen Uptake Revealed by Optic Fiber Microsensor.Investigative ophthalmology & visual science · 2024Article
- Trabecular Meshwork Mitochondrial Function and Oxidative Stress: Clues to Racial Disparities of Glaucoma.Ophthalmology science · 2022Article
- Factors determining barrier properties to oxygen transport across model and cell plasma membranes based on EPR spin-label oximetry.Applied magnetic resonance · 2021Article
- Functional imaging of mitochondria in retinal diseases using flavoprotein fluorescence.Eye (London, England) · 2021Review
- Intraocular Oxygen and Antioxidant Status: New Insights on the Effect of Vitrectomy and Glaucoma Pathogenesis.American journal of ophthalmology · 2019Article
- Effects of Vitrectomy and Lensectomy on Older Rhesus Macaques: Oxygen Distribution, Antioxidant Status, and Aqueous Humor Dynamics.Investigative ophthalmology & visual science · 2017Article
- Organization of lipids in fiber-cell plasma membranes of the eye lens.Experimental eye research · 2017Review
- Mitochondrial oxygen metabolism in primary human lens epithelial cells: Association with age, diabetes and glaucoma.Free radical biology & medicine · 2016Article
- Impact of Corneal Endothelial Dysfunctions on Intraocular Oxygen Levels in Human Eyes.Investigative ophthalmology & visual science · 2015Article
- Central corneal thickness correlates with oxygen levels in the human anterior chamber angle.American journal of ophthalmology · 2015Article
- Influence of posterior vitreous detachment and type of intraocular lens on lipid peroxidation in the human vitreous.Molecular vision · 2015Article
- Preserve the (intraocular) environment: the importance of maintaining normal oxygen gradients in the eye.Japanese journal of ophthalmology · 2014Review
- Mathematical modeling approaches in the study of glaucoma disparities among people of African and European descents.Journal of coupled systems and multiscale dynamics · 2013Article
- Article
- Comparative Evaluation of Corneal Endothelium in Diabetic Patients Undergoing Phacoemulsification.Middle East African journal of ophthalmologyArticle
- Comparative Evaluation of Corneal Endothelium in Patients with Diabetes Undergoing Phacoemulsification.Middle East African journal of ophthalmologyArticle
- Evaluation and Comparison of the Indices of Systemic Oxidative Stress among Black-Africans with Age-related Cataracts or Primary Glaucoma.Middle East African journal of ophthalmologyArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveTo compare the Po(2) distribution in different regions in the eyes of patients undergoing intraocular surgery.
methodsBefore initiation of intraocular cataract and/or glaucoma surgery, an optical oxygen sensor was introduced into the anterior chamber via a peripheral corneal paracentesis. The tip of the flexible fiberoptic probe was positioned by the surgeon for 3 measurements in all patients: (1) near the central corneal endothelium, (2) in the mid-anterior chamber, and (3) in the anterior chamber angle. In patients scheduled to undergo cataract extraction, Po(2) was also measured (4) at the anterior lens surface and (5) in the posterior chamber just behind the iris. Oxygen measurements at the 5 locations were compared using a 2-tailed unpaired t test and multivariate regression.
resultsThe Po(2) value was significantly higher in African American patients at all 5 locations compared with Caucasian patients. Adjusting for age increased the significance of this association. Adjusting for race revealed that age was associated with increased Po(2) beneath the central cornea.
conclusionsRacial differences in oxygen levels in the human eye reflect an important difference in oxidative metabolism in the cornea and lens and may reflect differences in systemic physiologic function. Increased oxygen or oxygen metabolites may increase oxidative stress, cell damage, intraocular pressure, and the risk of developing glaucoma. Oxygen use by the cornea decreases with age.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.