SynthesisArchives of ophthalmology (Chicago, Ill. : 1960)2011
Effect of age on response to amblyopia treatment in children.
Synthesis in Archives of ophthalmology (Chicago, Ill. : 1960), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 139 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Standard Amblyopia Therapy in Adult Amblyopes
Valproate for the Treatment of Residual Amblyopia
Who cites it
139 citing papers in PubMed, 8 syntheses or guidelines pooled it, 359 citations in OpenAlex.
- Interventions for improving adherence to amblyopia treatments in children.The Cochrane database of systematic reviews · 2025Pooled it
- Spontaneous recovery from amblyopia following fellow eye vision loss: a systematic review and narrative synthesis.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2024Pooled it
- Brazilian best practice guidelines for amblyopia diagnosis and management.Arquivos brasileiros de oftalmologia · 2024Guideline
- Home-based screening tools for amblyopia: a systematic review.Eye (London, England) · 2023Pooled it
- Pediatric Eye Evaluations Preferred Practice Pattern.Ophthalmology · 2023Guideline
- Amblyopia Preferred Practice Pattern.Ophthalmology · 2023Guideline
- Binocular versus standard occlusion or blurring treatment for unilateral amblyopia in children aged three to eight years.The Cochrane database of systematic reviews · 2022Pooled it
- Vision screening for children 36 to <72 months: recommended practices.Optometry and vision science : official publication of the American Academy of Optometry · 2015Guideline
- Factors associated with visual acuity improvement with a binocular digital therapeutic for amblyopia.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2023Trial
- Randomized clinical trial of streaming dichoptic movies versus patching for treatment of amblyopia in children aged 3 to 7 years.Scientific reports · 2022Trial
- Prediction of cycloplegic refraction for noninvasive screening of children for refractive error.PloS one · 2021Trial
- Baseline and Clinical Factors Associated with Response to Amblyopia Treatment in a Randomized Clinical Trial.Optometry and vision science : official publication of the American Academy of Optometry · 2020Trial
- A Randomized Trial of Binocular Dig Rush Game Treatment for Amblyopia in Children Aged 7 to 12 Years.Ophthalmology · 2019Trial
- The Effect of Combined Patching and Citalopram on Visual Acuity in Adults with Amblyopia: A Randomized, Crossover, Placebo-Controlled Trial.Neural plasticity · 2019Trial
- Fluoxetine does not enhance the effect of perceptual learning on visual function in adults with amblyopia.Scientific reports · 2018Trial
- Atropine vs patching for treatment of moderate amblyopia: follow-up at 15 years of age of a randomized clinical trial.JAMA ophthalmology · 2014Trial
- Causes of Reduced Vision in Australian Children.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Equivalent effectiveness of a prescription binocular treatment for amblyopia in real-world practice.Journal of managed care & specialty pharmacy · 2026Article
- Cortico-retinal decoupling in anisometropic amblyopia: OCTA-VEP multimodal biomarkers reveal neurovascular mismatch patterns.BMC ophthalmology · 2026Article
- Are amblyopia therapy outcomes related to socioeconomic situation for children in Greater Manchester?Eye (London, England) · 2026Article
79 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo determine whether age at initiation of treatment for amblyopia influences the response among children 3 to less than 13 years of age with unilateral amblyopia who have 20/40 to 20/400 amblyopic eye visual acuity.
methodsA meta-analysis of individual subject data from 4 recently completed randomized amblyopia treatment trials was performed to evaluate the relationship between age and improvement in logMAR amblyopic eye visual acuity. Analyses were adjusted for baseline amblyopic eye visual acuity, spherical equivalent refractive error in the amblyopic eye, type of amblyopia, prior amblyopia treatment, study treatment, and protocol. Age was categorized (3 to <5 years, 5 to <7 years, and 7 to <13 years) because there was a nonlinear relationship between age and improvement in amblyopic eye visual acuity.
resultsChildren from 7 to less than 13 years of age were significantly less responsive to treatment than were younger age groups (children from 3 to <5 years of age or children from 5 to <7 years of age) for moderate and severe amblyopia (P < .04 for all 4 comparisons). There was no difference in treatment response between children 3 to less than 5 years of age and children 5 to less than 7 years of age for moderate amblyopia (P = .67), but there was a suggestion of greater responsiveness in children 3 to less than 5 years of age compared with children 5 to less than 7 years of age for severe amblyopia (P = .09).
conclusionsAmblyopia is more responsive to treatment among children younger than 7 years of age. Although the average treatment response is smaller in children 7 to less than 13 years of age, some children show a marked response to treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.